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Filtering by: Creator Wickramasekara, S. Subject Proteomics

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Creator:

Huang, Lin

Abstract:

Oxidative stress is deﬁned as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...

Resource Type:

Dissertation

Full Text:

Abstract approved: ______________________________________________________ Claudia S. Maier
Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Creator:

Tzeng, Shin-Cheng

Abstract:

Alcoholic liver disease (ALD) continues to be one of the major public health problems in the United States and worldwide. Complicated by factors including gender, polymorphisms of alcohol-metabolizing enzymes, immunologic factors, exposures to other substances/drugs, hepatic viral infections, nutritional deficiencies, and obesity, ALD is a complex disease that requires a...

Resource Type:

Dissertation

Full Text:

Model Abstract approved: Dr. Claudia S. Maier Alcoholic liver disease (ALD