Several compounds have been shown to induce the mixed function
oxidase enzyme system of animals, and also to inhibit tumor formation.
Included in this category are several vegetables and isolated
vegetable components from the Cruciferae family. In this
study rainbow trout were fed blanched freeze-dried cauliflower,
broccoli, or Brussel sprouts...
Whole body accumulation and tissue distribution of dieldrin
(HEOD1) in rainbow trout was studied through oral dose disposition
tests and subchronic exposures via water (0.04 and 0.08 jig dieldrin/l)
and/or diet (0.087 jig dieldrin/g fish/day). Growth and maintenance
rations of 4 and 2% body weight/day were employed. Subchronic testing
produced...
Triplicate groups of rainbow trout (Salmo gairdneri) fed six
diets; five based on fish protein concentrate (FPC) ranging in caloric
density from 4.36 to 6.19 kcal/g, and one based on vitamin free
casein with a caloric density of 5.26 kcal/g were evaluated with
respect to diet ingredient utilization. The parameters...
Three studies were conducted to determine the effects of
cyclopropenoid fatty acids (CPFA) on the membrane components of livers
of rainbow trout (Salmo gairdneri). In the first study, ¹⁴C-sterculic
acid was administered by intraperitoneal injection into rainbow trout
and the trout maintained for 72 hours. The labelled sterculic acid
was...
The induction of drug-metabolizing enzymes is a
complex biochemical process manifested not only by
increases in various cytochrome P-450 isozymes and
related activities, but also by alterations in
endoplasmic reticulum membranes. Little work has been
done to examine how cytochrome P-450 inducing agents
influence other cellular processes, such as
phospholipid...
Three studies were conducted to evaluate the relationship between
insulin and nutritional parameters in rainbow trout. In the first study
effects on growth parameters and tissue composition of rainbow trout were
investigated following injection of bovine insulin at two dose levels
every 48 hr for 56 days. In addition, [¹⁴C]-leucine...
Aflatoxin B₁ (AFB₁) is a mold-produced toxin which has been shown
to be a potent hepatocarcinogen in many animal species. Of the
species studied thus far, rainbow trout have proven to be the most
sensitive. Experiments were conducted to investigate various aspects
of AFB₁ metabolism in this species, including in...
This study was conducted to investigate the accumulation of dietary polychlorinated biphenyls (PCB's) by a Mt. Shasta strain of rainbow trout (Salmo gairdneri). A commercial mixture of PCB's (Aroclor 1254) was added to the diet at a level of 15 ppm on a dry weight basis. Accumulation of PCB's was...
The DNA repair capabilities of rainbow trout (Salmo gairdneri)
were studied vising the method of autoradiography. Trout were fed a
semi-purified control diet containing 0 ppm, 50 ppm, or 300 ppm
cyclopropenoid fatty acids (CPFA) for 6-9 weeks. Liver slices were
prepared and exposed in vitro to a control treatment,...