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Filtering by: Subject Ranitidine -- Pharmacokinetics Subject Phenylbutazone -- Pharmacokinetics

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Creator:

Ma, Lian

Abstract:

The first part of the dissertation is to evaluate the use of proposed and established equations for area under the plasma concentration versus time (AUC) for molecules undergoing nonlinear Michaelis–Menten pharmacokinetic elimination. The effects of varying Michaelis-Menten parameters, rate of drug absorption, or bioavailability on the predictability of drug exposure...

Resource Type:

Dissertation