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Filtering by: Creator Guerrero, Ernesto R. Remove constraint Creator: Guerrero, Ernesto R. Subject Ras oncogenes Remove constraint Subject: Ras oncogenes

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  • Analysis of ras gene mutations in rainbow trout tumors

    Creator:
    Chang, Yung-jin
    Abstract:
    For ras gene mutation analysis in the rainbow trout (Oncorhynchus mykiss) model system, a partial trout ras sequence was identified using the polymerase chain reaction (PCR). Two synthetic oligonucleotides based on rat K-ras gene sequence were used as primers for the PCR procedure. A 90 base pair (bp) sequence, referred...
    Resource Type:
    Dissertation
    Full Text:
    (Guerrero et al., 1984; Guerrero et al., 1985) and in rat (McMahon et al., 1990b). Ras gene family shares

  • Ras oncogenes and p53 suppressor genes in fish carcinogenesis models

    Creator:
    Cheng, Ronshan
    Abstract:
    A digoxigenin-labeled nonradioactive detection system was used to screen a zebrafish cDNA library for p53-like and ras-like genes. One clone was isolated and identified as an incomplete p53-like gene. The insert size of this clone is 1777 bp, which encodes part of evolutionarily conserved region II and all of regions...
    Resource Type:
    Dissertation
    Full Text:
    APPROVED: Major Professor, representing Food Science and Technology r r Chair of Department of Food

  • Characterization of a ras gene in rainbow trout

    Creator:
    Mangold, Kathy A.
    Abstract:
    The rainbow trout (Oncorhynchus mykiss) model of chemical carcinogenesis is becoming increasingly important as a supplement to rodent studies. However, much of the molecular biology of the carcinogenic response is still unknown in the trout model. The ras gene family has been implicated in the tumorigenesis of both spontaneous and...
    Resource Type:
    Dissertation
    Full Text:
    al., 1986 6 George et al., 1985 7 Nemoto et al., 1986 8 Taparowsky et al., 1983 9 Guerrero et al

  • Studies of rainbow trout Ki-ras gene : sequencing, aflatoxin B1 binding, and chromatin structure

    Creator:
    Liang, Xiaoshan
    Abstract:
    Characterization of the 5' flanking region of rainbow trout ki-ras gene was begun with the cloning and sequencing of this region by the inverse PCR technique and dideoxynucleotide chain termination method. In total, a nucleotide sequence of 1080 bp upstream from the first coding ATG was sequenced. Although this region...
    Resource Type:
    Dissertation
    Full Text:
    preference of the initial adduction in vivo. Studies of Rainbow Trout Ki-r as Gene: Sequencing, Aflatoxin