Rat luteal cells from functional and non-functional
corpora lutea (corpora lutea rendered non-functional by
hypophysectomy) were preserved for light and electron
microscopy in Bouin's and glutaraldehyde-osmium fixation
respectively. Material for electron microscopy was dehydrated
with ethanol, embedded in Araldite and stained
with lead hydroxide or uranyl acetate-lead citrate. Examination
of...
Normal adult rats absorbed and metabolized C¹⁴-labeled acetate
rapidly. The greatest percentage of the administered radioactivity
was recovered in the expired CO₂, however small amounts of radioactivity
were also found in the urine and feces. There were two rates
of C¹⁴O₂ elimination in normal adult rats. The small amount of...
There has been no toxicologic proof that the long-term, low-level
exposure of man to chlorophenothane (DDT) is linked with an
increased susceptibility to toxicity or disease. Acute pretreatment
of rats with 75-100 mg/kg DDT has been demonstrated to potentiate
CCI₄-induced hepatotoxicity in that species (McLean and McLean,
1966). Since the...
Virtually nothing is known regarding the quantitative significance
of the several catabolic sequences involved in the breakdown of
glucose in the intact rat. Studies in this and other laboratories have
shown that the Embden-Meyerhof-Parnas pathway, the pentose
phosphate pathway and the glucuronic acid pathway are operative in
several tissues of...
Preliminary toxicity studies of BCNU in rats revealed that significant
prolongations of pentobarbital hypnosis were associated with
all doses employed. Investigations were undertaken to determine the
underlying mechanism responsible for this observed effect. Studies
on the in vitro metabolism of pentobarbital by hepatic microsomes
of BCNU-treated animals demonstrated that significant...
A single oral dose of DDT, ranging from 40 to 200 mg/kg, had
a drastic effect on the in vivo acetate metabolism in rats. The normal
elimination pattern of the expired ¹⁴CO₂ from ¹⁴C-labelled
acetate was distorted, and the rate of output of the ¹⁴CO₂ was decreased.
The ratio of...