Previous investigations of the biosynthesis of sterols by the
arterial wall have shown that the intact aorta is capable of low level
incorporation of labeled precursor into a sterol digitonide. The biosynthesis
of sterols and related lipids by a cell-free preparation of
bovine aorta was investigated in the present study....
Dihalocarbenes have been generated mainly by thermal decomposition
of sodium trihaloacetate and phenyl (trihalomethyl)mercury,
and give gem-dihalocyclopropyl adducts with various steroid olefins.
A new procedure involving the use of sealed tubes makes possible the
addition of dihalocarbenes to sterically hindered olefins. In this manner,
7-cholestenyl benzoate when treated with PhHgCC1₃...
Steroid carbenes have been investigated as synthetic intermediates.
Basic decomposition of 4-en-3-one tosylhydrazones (and
other A-ring systems) gives varying amounts of 2, 4-dienes, and
solvent derived products with diglyme, heptane, tetrachloroethylene,
carbon tetrachloride, benzene and cyclohexene. A method for
separating complex product mixtures was developed and a study of
the...