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  • Large volume (1,800 µL) injection HPLC/MS/MS for the quantitative determination of illicit drugs and human urinary biomarkers in municipal wastewater

    Creator:
    Chiaia Hernandez, Aurea C.
    Abstract:
    A sensitive, selective, rapid analytical method based on large-volume injection (LVI) liquid chromatography/ tandem mass spectrometry was developed using commercially-available hardware that eliminates the need for either off-line or on-line solid phase extraction. Centrifugation followed by the direct injection of 1,800 µL was used for the quantification of illicit drugs,...
    Resource Type:
    Masters Thesis
    Full Text:
    ) liquid chromatography/ tandem mass spectrometry was developed using commercially-available hardware

  • Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

    Creator:
    Wang, Jing
    Abstract:
    Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
    Resource Type:
    Dissertation
    Full Text:
    commonly used mass analyzers in this field include the quadrupole (Q), ion trap (IT), time-of-flight (TOF

  • Gas-phase fragmentation chemistry of protonated peptide ions

    Creator:
    Bythell, Benjamin James
    Abstract:
    The fragmentation characteristics of protonated peptides have been investigated using tandem mass spectrometry (MS/MS) under various fragmentation regimes and detailed density functional theory (DFT) reaction pathway calculations. The DFT calculations predict novel salt-bridge stabilized transition structures as well as consecutive reactions occurring in proton-bound dimers for some of the ions...
    Resource Type:
    Dissertation
    Full Text:
    …………………..............………....... 7 1.2.3.3 Time-of-flight Mass Spectrometry ………………….................... 8 1.2.3.3.1 MALDI

  • Tandem mass spectrometric analysis of protein and peptide adducts of lipid peroxidation-derived aldehydes

    Creator:
    Wu, Jianyong
    Abstract:
    The adduction of proteins and other biomolecules by electrophilic lipid peroxidation products such as 4-hydroxy-2-nonenal (HNE), 4-oxo-2-nonenal (ONE), malondialdehyde (MDA) or acrolein (ACR) is thought to be an initiating and/or propagating factor in the pathophysiology of several diseases such as atherosclerosis, diabetes, Alzheimer's, Parkinson's and other age-related disorders. The identification...
    Resource Type:
    Dissertation
    Full Text:
    , Brian Arbogast, Jeff Morre and the rest of the mass spectrometry group for their support. Thanks are