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Filtering by: Creator Kuriyama, Y. Remove constraint Creator: Kuriyama, Y. Subject Tetrachlorodibenzodioxin -- Toxicology Remove constraint Subject: Tetrachlorodibenzodioxin -- Toxicology

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Characterization of pyruvate carboxylase responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in C57BL/6J male Ah[superscript d/d] mice

Creator:

Ryu, Byung-Woo

Resource Type:

Dissertation

Full Text:

lethality. Biochem. Biophy. Res. Comm. 174: 1267 1271. Mackay, D., Shiu, W.-Y., and Ma, K (1992
Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

Creator:

Rohlman, Diana

Abstract:

The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...

Resource Type:

Dissertation
Regulation of hepatic pyruvate carboxylase in 2,3,7,8-Tetrachlorodibenzo-p-dioxin treated C57BL/6J mice and their pair-fed controls

Creator:

Roy, Shukla

Resource Type:

Dissertation
The influence of aryl hydrocarbon receptor activation on T cell fate

Creator:

Funatake, Castle J.

Abstract:

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...

Resource Type:

Dissertation

Full Text:

. Th 1 cells secrete interleukin (IL)-2 and interferon (IFN)-y, and promote the development of cell
Investigations of regulatory T cell induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin during a graft-versus-host response

Creator:

Marshall, Nikki B.

Abstract:

The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...

Resource Type:

Dissertation

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Academic Affiliation

Environmental and Molecular Toxicology2
Microbiology1

Advisor

Kerkvliet, Nancy I.2
Kerkvliet, Nancy1
Schaup, Henry W.1
Selivonchick, Daniel P.1

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 1997 to 2014

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Committee Member

Leid, Mark3
Bayne, Christopher1
Blythe, Linda L.1
Buermeyer, Andrew1
Buhler, Donald R.1
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Creator

Funatake, Castle J.1
Marshall, Nikki B.1
Rohlman, Diana1
Roy, Shukla1
Ryu, Byung Woo1

Date

Date range begin – Date range end

Current results range from 1996 to 2013

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Decade

2010-20191
2000-20092
1990-19992

Degree Field

Toxicology4
Microbiology1

Degree Level

Doctoral5

Degree Name

Doctor of Philosophy (Ph.D.)5

Language

English [eng]5

License

All rights reserved2

Non-Academic Affiliation

Oregon State University. Graduate School5

Peer Reviewed

No5

Resource Type

Dissertation5

Rights Statement

In Copyright3
Copyright Not Evaluated2

Subject

Tetrachlorodibenzodioxin -- Toxicology[remove]5
Genetic toxicology1
Genetic transcription -- Regulation1
Graft versus host disease1
Graft versus host reaction1
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