Index Catalog // ScholarsArchive@OSU

Effects of nucleosomes on transcription by polymerase I in a reconstituted system

Creator:: Georgel, Philippe, 1961-
Abstract:: The aim of this study was to gain more information about the interactions between DNA and the histone octamer during the process of transcription. This work used a pUC8 plasmid derivative that contained the core promoter region of the RNA polymerase I of Acanthamoeba castellanii, placed upstream of four repeats...
Resource Type:: Dissertation
Full Text:: Redacted for Privacy ACKNOWLEDGMENTS I would like to express special thanks to: Professor Ken van Ho

The function of the homeobox transcription factor Pitx2 during mammalian skeletal muscle development

Creator:: Shih, Hung Ping
Abstract:: Homeodomain transcription factors control developmental processes. They pattern body formation, specify cell lineages and switch the onset of gene regulatory cascades. Pitx2, a bicoid-related homeodomain transcription factor, is asymmetrically expressed in the left lateral plate mesoderm and mesoderm-derived tissues. Pitx2 null mice are characterized by failure of body wall closure,...
Resource Type:: Dissertation
Full Text:: anlagen, which results to loss of MAM (Dong et al., 2006; Shih et al., 2007b; Fig. 2A, B). Both Pax3 and

Transcription factor CTIP2 regulates hair follicle development, hair cycling and wound healing

Creator:: Bhattacharya, Shreya
Abstract:: The integumentary system is the largest organ system of the body that comprises of skin and its appendages such as hair follicles, sebaceous and sweat glands. Skin is divided into three distinct structural layers: the epidermis, dermis and hypodermis. The epidermis originates from the ectoderm and is composed of four...
Resource Type:: Dissertation
Full Text:: . Cell 31:11-24. Muller-Rover S, Handjiski B, van der Veen C, et al. (2001) A comprehensive guide for

The role of the transcriptional regulatory protein BCL11B in dental and craniofacial development

Creator:: Kyrylkova, Kateryna
Abstract:: BCL11B is a transcriptional regulatory protein that plays essential roles during mouse embryonic development. BCL11B is expressed and functions in the immune and nervous systems as well as within ectodermal organs. Multiple studies have characterized the roles of BCL11B in T cells, brain, and skin. However, very little is known...
Resource Type:: Dissertation
Full Text:: genotypic information will allow us to create a functional map of mammalian genome (Nguyen and Xu, 2008

Gene networks during cardiogenesis and skeletal myogenesis

Creator:: Ma, Hsiao-Yen
Abstract:: Organismal development requires a precisely orchestrated transcriptional program to correctly deploy genetic information into the genome. This process requires sophisticated gene regulatory networks at multiple spatial and temporal levels from early embryonic development to adult physiological conditions. Molecular differences that define cell types are set up during the pattern formation...
Resource Type:: Dissertation

Roles of homeodomain transcription factors during organogenesis

Creator:: Xu, Jun
Abstract:: The spatial and temporal patterning of sequence specific transcription factors (SSTFs) contributes to cell type specification and organ formation during embryogenesis. Homeodomain transcription factors are evolutionally conserved among invertebrate and vertebrate animals. They are responsible for body segmentation and organogenesis. Lbx1 and Pitx2 both are homeodomain transcription factors contributing to...
Resource Type:: Dissertation
Full Text:: , Nguyen HD, Kemler R, Glass CK, Wynshaw-Boris A, Rosenfeld MG (2002) Identification of a Wnt/Dvl/beta

Gene regulatory networks during muscle development

Creator:: Eng, Diana G.
Abstract:: Congenital myopathies are caused by heritable mutations in particular genes. Genes mutated in congenital muscular dystrophies often encode cytoskeletal proteins, which contribute to the shape and movement of cells. We would like to know how such molecular defects lead to the muscle weakness in patients. It is therefore important to...
Resource Type:: Dissertation
Full Text:: , puberty, and fertility. Genesis 46, 507-514. Chen, Y., Dong, E., and Grayson, D.R. (2011). Analysis of

Transcriptional networks controlled by the fatty acid regulators FAR-1 and FAR-2

Creator:: Bredeweg, Erin L.
Abstract:: Fungi are capable of growth on a wide variety of carbon sources, both living and dead. They can produce an arsenal of enzymes and transporters for harvesting sugars, polysaccharides, amino acids, lipids and micronutrients from their environments [1]. Within the nucleus of a cell, transcription factors (TF) control whether genes...
Resource Type:: Dissertation

Role of Transcriptional Factor COUP-TF-interacting Proteins in Skin Permeability Barrier Development, and in Skin Carcinogenesis, and Role of Lipids in Atopic Dermatitis

Creator:: Li, Shan
Abstract:: Mammalian skin is the largest organ of the body and serves as a barrier to protect the body against chemical, mechanical and pathogenic insults as well as water loss. The epidermis is formed from the primitive ectoderm into a multilayered stratified epithelium, consisting of basal, spinous, granular and outermost cornified...
Resource Type:: Dissertation
Full Text:: . Cold Spring Harb Perspect Biol, 2012. 4(7): p. a008383. 10. van Smeden, J., et al., The important

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Creator:: Smith, Eric Jonathan
Abstract:: Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...
Resource Type:: Dissertation

ScholarsArchive@OSU

Effects of nucleosomes on transcription by polymerase I in a reconstituted system

The function of the homeobox transcription factor Pitx2 during mammalian skeletal muscle development

Transcription factor CTIP2 regulates hair follicle development, hair cycling and wound healing

The role of the transcriptional regulatory protein BCL11B in dental and craniofacial development

Gene networks during cardiogenesis and skeletal myogenesis

Roles of homeodomain transcription factors during organogenesis

Gene regulatory networks during muscle development

Transcriptional networks controlled by the fatty acid regulators FAR-1 and FAR-2

Role of Transcriptional Factor COUP-TF-interacting Proteins in Skin Permeability Barrier Development, and in Skin Carcinogenesis, and Role of Lipids in Atopic Dermatitis

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

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