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Filtering by: Creator Chou, Chia-Fu Subject Viral genetics

Molecular study of the cytopathic mechanisms of infectious hematopoietic necrosis virus in vivo and in vitro

Creator:

Anderson, Eric David

Abstract:

Molecular biological approaches were used to study and interfere with the life cycle of infectious hematopoietic necrosis virus (IHNV). These included the control of IHN disease in rainbow trout by genetic immunization or interference in vitro by synthesis of sense and antisense expression of the viral nucleocapsid (N) gene, and...

Resource Type:

Dissertation
Translation of dengue virus RNA : influence of the untranslated regions on 5´-cap dependent translation and ribosome scanning

Creator:

Chiu, Wei-Wei

Abstract:

In this thesis, I studied the translation of dengue virus RNA using a luciferase reporter gene system in Vero cells. The dengue reporter mRNA construct, which harbors 5´-terminal viral nts and 3´-terminal nts, could be translated efficiently compared to an alpha globin reporter construct. The 5´-cap structure and 3´-untranslated region...

Resource Type:

Dissertation