Index Catalog // ScholarsArchive@OSU

Targeted development of antivirals against influenza A and respiratory syncytial virus

Creator:: Lupfer, Christopher
Abstract:: Influenza A and Respiratory Syncytial Virus (RSV) are both enveloped, negative strand RNA viruses which infect the respiratory mucosa of animals and humans. Despite decades of research and development of antivirals and vaccines, both of these viruses continue to be a major health concern throughout the world. The focus of...
Resource Type:: Dissertation
Full Text:: Development of Antivirals against Influenza A and Respiratory Syncytial Virus. Abstract approved

Analysis of two highly expressed genes from Chlorella virus PBCV- 1 ; prote in characterization and the DNA sequences of the major capsid protein gene and the early/late 33-kDa protein gene

Creator:: Graves, Michael V.
Resource Type:: Dissertation
Full Text:: expressed genes from a single viral isolate. The gene encoding the capsid protein (Vp54) from virus PBCV-1

Molecular study of the cytopathic mechanisms of infectious hematopoietic necrosis virus in vivo and in vitro

Creator:: Anderson, Eric David
Abstract:: Molecular biological approaches were used to study and interfere with the life cycle of infectious hematopoietic necrosis virus (IHNV). These included the control of IHN disease in rainbow trout by genetic immunization or interference in vitro by synthesis of sense and antisense expression of the viral nucleocapsid (N) gene, and...
Resource Type:: Dissertation
Full Text:: expression of the viral nucleocapsid (N) gene, and in situ localization of the virus in infected fish. The

Proteolytic maturation of vaccinia virus structural proteins

Creator:: VanSlyke, Judy K.
Abstract:: Vaccinia virus (VV) is a large DNA virus belonging to the Orthopoxvirus family. The viral replicative life cycle takes place solely within the cytoplasm of a mammalian host cell. The VV genome contains 196 open reading frames which are expressed in a highly regulated and temporal fashion in order to...
Resource Type:: Dissertation
Full Text:: I I. 1 Vaccinia virus replication strategy 2 I. 2 Levels of regulation of gene expression during 6

Replication of vaccinia virus in the presence of 1,10-phenanthroline

Creator:: ApRoberts, Robyn E.
Abstract:: 1,10-phenanthroline and its non-chelating isomer, 1,7-phenanthroline were used to inhibit the replication of vaccinia virus (VV). Serial passage of VV in the presence of various concentrations of either 1,10-phenanthroline or 1,7-phenanthroline was carried out. No drug resistant mutants were isolated, suggesting that the observed inhibition was due to a cellular...
Resource Type:: Masters Thesis
Full Text:: represent the major stages of the virus life cycle. 1) Uncoating I. 2) Early gene expression. 3) Uncoating

Genomic characterization of a novel leporid Herpes simplex virus

Creator:: Babra, Bobby A.
Abstract:: The viral family Herpesviridae consists of large double stranded DNA viruses including eight species that infect humans with varying pathology from benign rashes to cancerous cell transformation. From three subfamilies, alpha-, beta- and gammaherpes, the alphaherpes contains the genera iltovirus, mardivirus, varicellovirus and simplex, two of which, the human simplex...
Resource Type:: Dissertation
Full Text:: core protein coding genes with notable variation in the IE gene, ICP34.5 (a neurovirulent factor), a

The conserved biology of herpesvirus latency : a study in cyprinid herpesvirus 3

Creator:: Reed, Aimee N.
Abstract:: Cyprinid herpesvirus 3 (CyHV-3), commonly known as koi herpesvirus (KHV), is a member of the Alloherpesviridae and is a deadly pathogen for koi and common carp, Cyprinus carpio. It causes severe gill necrosis and nephritis, dermal ulceration and hemorrhage, and mass mortality of up to 100% of affected fish. Fish...
Resource Type:: Dissertation
Full Text:: of host protein synthesis inhibitors. These genes are typically involved in viral gene

Disulphide bond formation is essential for vaccinia virus late protein L1R function and for production of infectious progeny

Creator:: Blouch, Robert Edward
Abstract:: L1R, a myristylated late gene product of vaccinia virus, is essential for formation of infectious intracellular mature virions (IMV). In its absence, only viral particles arrested at an immature stage are detected and no infectious progeny virus are produced. Previous studies have shown that the L1R protein is exclusively associated...
Resource Type:: Masters Thesis
Full Text:: Progeny. approved: DennisE. Hruby LIR, a myristylated late gene product of vaccinia virus, is essential

Translation of dengue virus RNA : influence of the untranslated regions on 5´-cap dependent translation and ribosome scanning

Creator:: Chiu, Wei-Wei
Abstract:: In this thesis, I studied the translation of dengue virus RNA using a luciferase reporter gene system in Vero cells. The dengue reporter mRNA construct, which harbors 5´-terminal viral nts and 3´-terminal nts, could be translated efficiently compared to an alpha globin reporter construct. The 5´-cap structure and 3´-untranslated region...
Resource Type:: Dissertation
Full Text:: thesis, I studied the translation of dengue virus RNA using a luciferase reporter gene system in Vero

OpMNPV p87, a baculovirus capsid protein : genetic location, nucleotide sequence, transcriptional mapping and immunochemical characterization

Creator:: Müller, Rolf
Abstract:: A capsid protein termed p87 of the Orgyia pseudotsugata multicapsid nuclear polyhedrosis virus (OpMNPV) was located to the HindIII-G fragment of the viral genome by Southern hybridization. A 3.6 kb segment of this region was sequenced and an 1872-nt open reading frame encoding the p 87 protein was identified and...
Resource Type:: Masters Thesis
Full Text:: Classification 2 Life cycle of occluded baculovirus 3 Gene expression 4 Structural genes and proteins 6 Proteins

ScholarsArchive@OSU

Targeted development of antivirals against influenza A and respiratory syncytial virus

Analysis of two highly expressed genes from Chlorella virus PBCV- 1 ; prote in characterization and the DNA sequences of the major capsid protein gene and the early/late 33-kDa protein gene

Molecular study of the cytopathic mechanisms of infectious hematopoietic necrosis virus in vivo and in vitro

Proteolytic maturation of vaccinia virus structural proteins

Replication of vaccinia virus in the presence of 1,10-phenanthroline

Genomic characterization of a novel leporid Herpes simplex virus

The conserved biology of herpesvirus latency : a study in cyprinid herpesvirus 3

Disulphide bond formation is essential for vaccinia virus late protein L1R function and for production of infectious progeny

Translation of dengue virus RNA : influence of the untranslated regions on 5´-cap dependent translation and ribosome scanning

OpMNPV p87, a baculovirus capsid protein : genetic location, nucleotide sequence, transcriptional mapping and immunochemical characterization

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