Toxin production by cyanobacterial harmful algal blooms (cyanoHABs) in freshwater systems has lasting ecological and human impacts. Nutrients, light availability, hydrology, and microbial community composition impact the frequency and intensity of toxic cyanoHABs. Climate change will exacerbate toxic cyanoHABs, making real time and predictive monitoring a vital tool for managing...
To examine the macrophage response to M. avium, I compared inflammasome and cytosolic sensor expression and activation. My result demonstrated that virulent strains of M. avium (A5 and 104) suppress IL-1β production and induce IFN-β production in macrophages. M. avium mutants deficient at DNA export in the biofilm exhibited reduced...
Having a series of excellent properties, the oxide dispersion-strengthened (ODS) steels provide promising solutions for the challenges of structural materials in nuclear energy, especially the development of future advanced nuclear fission and even fusion reactors. The current manufacturing route for ODS alloys includes mechanical alloying (MA) of master alloys or...
How can software practitioners assess whether their software supports diverse users? Although there are empirical processes that can be used to find “inclusivity bugs” piecemeal, what is often needed is a systematic inspection method to assess software’s support for diverse populations. To help fill this gap, this thesis introduces InclusiveMag,...
Igneous oceanic crust encompasses ~60% of Earth’s surface and is composed of basalt glass and mafic, ultramafic, and felsic minerals. A vast marine aquifer lies within the crust, exchanging geochemically altered fluids with seawater from the overlying ocean at ridge crests, flanks, seamounts, and outcrops where permeable crust is exposed....
The complex, dynamic nature of microbial communities in both natural and engineered environments complicates the work of scientists and engineers who wish to channel microbial interactions for societal good. The successful management of these communities towards engineering goals is dependent on developing predictive linkages between community structure and functional outputs....
Globally, as surface water quality and quantity diminishes there is increasing reliance on groundwater to buffer water demands of growing populations. Today in many arid regions around the world aquifer pumping rates far exceed recharge rates. Often the groundwater is nonrenewable, or thousands of years old. Despite the known hydrologic...
The development of nanomaterials and the potential enhancement of their chemical, mechanical, electrical, and optical properties have led to the investigation of methods for their synthesis at lower cost with enhanced performance for next generation devices. Along with the pursuit of new materials that exhibit properties of interest, industry requires...
Despite the advance of biomedical science, infectious diseases remain one of the number one killers in the world. They claim the lives of millions of people annually, particularly in underdeveloped and developing countries. In fact, more than 32% of the health burden in Africa is caused by infectious diseases, e.g.,...