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- Creator:
- Tello-Ruiz, Marcela K., Stein, Joshua, Wei, Sharon, Preece, Justin, Olson, Andrew, Naithani, Sushma, Amarasinghe, Vindhya, Dharmawardhana, Palitha, Jiao, Yinping, Mulvaney, Joseph, Kumari, Sunita, Chougule, Kapeel, Elser, Justin, Wang, Bo, Thomason, James, Bolser, Daniel M., Kerhornou, Arnaud, Walts, Brandon, Fonseca, Nuno A., Huerta, Laura, Keays, Maria, Tanga, Y. Amy, Parkinson, Helen, Fabregat, Antonio, McKay, Sheldon, Weiser, Joel, D'Eustachio, Peter, Stein, Lincoln, Petryszak, Robert, Kersey, Paul J., Jaiswal, Pankaj, and Ware, Doreen
- Abstract:
- Gramene (http://www.gramene.org) is an online resource for comparative functional genomics in crops and model plant species. Its two main frameworks are genomes (collaboration with Ensembl Plants) and pathways (The Plant Reactome and archival BioCyc databases). Since our last NAR update, the database website adopted a new Drupal management platform. The...
- Full Text:
- Olson1, Sushma Naithani2, Vindhya Amarasinghe2, Palitha Dharmawardhana2, Yinping Jiao1, Joseph Mulvaney1
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- Creator:
- Sigl, Michael, Fudge, Tyler J., Winstrup, Mai, Cole-Dai, Jihong, Ferris, David, McConnell, Joseph R., Taylor, Ken C., Welten, Kees C., Woodruff, Thomas E., Adolphi, Florian, Bisiaux, Marion, Brook, Edward J., Buizert, Christo, Caffee, Marc W., Dunbar, Nelia W., Edwards, Ross, Geng, Lei, Iverson, Nels, Koffman, Bess, Layman, Lawrence, Maselli, Olivia J., McGwire, Kenneth, Muscheler, Raimund, Nishiizumi, Kunihiko, Pasteris, Daniel R., Rhodes, Rachael H., and Sowers, Todd A
- Abstract:
- We present the WD2014 chronology for the upper part (0–2850 m; 31.2 ka BP) of the West Antarctic Ice Sheet (WAIS) Divide (WD) ice core. The chronology is based on counting of annual layers observed in the chemical, dust and electrical conductivity records. These layers are caused by seasonal changes...
- Resource Type:
- Article
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- Creator:
- Tello-Ruiz, Marcela K., Stein, Joshua, Wei, Sharon, Preece, Justin, Olson, Andrew, Naithani, Sushma, Amarasinghe, Vindhya, Dharmawardhana, Palitha, Jiao, Yinping, Mulvaney, Joseph, Kumari, Sunita, Chougule, Kapeel, Elser, Justin, Wang, Bo, Thomason, James, Bolser, Daniel M., Kerhornou, Arnaud, Walts, Brandon, Fonseca, Nuno A., Huerta, Laura, Keays, Maria, Tanga, Y. Amy, Parkinson, Helen, Fabregat, Antonio, McKay, Sheldon, Weiser, Joel, D'Eustachio, Peter, Stein, Lincoln, Petryszak, Robert, Kersey, Paul J., Jaiswal, Pankaj, and Ware, Doreen
- Abstract:
- Gramene (http://www.gramene.org) is an online resource for comparative functional genomics in crops and model plant species. Its two main frameworks are genomes (collaboration with Ensembl Plants) and pathways (The Plant Reactome and archival BioCyc databases). Since our last NAR update, the database website adopted a new Drupal management platform. The...
- Resource Type:
- Article
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- Creator:
- Scavia, Donald, Allan, J. David, Arend, Kristin K., Brandt, Stephen B., Bartell, Steven, Bosch, Nate S., Briland, Ruth D., Daloğlu, Irem, DePinto, Joseph V., Dolan, David M., Evans, Mary Anne, Farmer, Troy M., Goto, Daisuke, Han, Haejin, Höök, Tomas O., Knight, Roger, Ludsin, Stuart A., Mason, Doran, Michalak, Anna M., Richards, R. Peter, Roberts, James J., Rucinski, Daniel K., Rutherford, Edward, Schwab, David J., Sesterhenn, Timothy M., Zhang, Hongyan, and Zhou, Yuntao
- Abstract:
- Relieving phosphorus loading is a key management tool for controlling Lake Erie eutrophication. During the 1960s and 1970s, increased phosphorus inputs degraded water quality and reduced central basin hypolimnetic oxygen levels which, in turn, eliminated thermal habitat vital to cold-water organisms and contributed to the extirpation of important benthic macroinvertebrate...
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- Article
- Full Text:
- addressing the re-eutrophication of Lake Erie: Central basin hypoxia Donald Scavia a,⁎, J. David Allan b
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- Creator:
- Stoltzfus, Arlin, Lapp, Hilmar, Matasci, Naim, Deus, Helena, Sidlauskas, Brian, Zmasek, Christian M., Vaidya, Gaurav, Pontelli, Enrico, Cranston, Karen, Vos, Rutger, Webb, Campbell O, Harmon, Luke J., Pirrung, Megan, O'Meara, Brian, Pennell, Matthew W., Mirarab, Siavash, Rosenberg, Michael S., Balhoff, James P., Bik, Holly M., Heath, Tracy A., Midford, Peter E., Brown, Joseph W., McTavish, Emily Jane, Sukumaran, Jeet, Westneat, Mark, Alfaro, Michael E., Steele, Aaron, and Jordan, Greg
- Abstract:
- Background: Scientists rarely reuse expert knowledge of phylogeny, in spite of years of effort to assemble a great “Tree of Life” (ToL). A notable exception involves the use of Phylomatic, which provides tools to generate custom phylogenies from a large, pre-computed, expert phylogeny of plant taxa. This suggests great potential...
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- Article
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- , James P Balhoff2, Holly M Bik16, Tracy A Heath17, Peter E Midford2, Joseph W Brown11, Emily Jane
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- Creator:
- Manning, Viola A., Pandelova, Iovanna, Dhillon, Braham, Wilhelm, Larry J., Goodwin, Stephen B., Berlin, Aaron M., Figueroa, Melania, Freitag, Michael, Hane, James K., Henrissat, Bernard, Holman, Wade H., Kodira, Chinnappa D., Martin, Joel, Oliver, Richard P., Robbertse, Barbara, Schackwitz, Wendy, Schwartz, David C., Spatafora, Joseph W., Turgeon, B. Gillian, Yandava, Chandri, Young, Sarah, Zhou, Shiguo, Zeng, Qiandong, Grigoriev, Igor V., Ma, Li-Jun, and Ciuffetti, Lynda M.
- Abstract:
- Pyrenophora tritici-repentis is a necrotrophic fungus causal to the disease tan spot of wheat, whose contribution to crop loss has increased significantly during the last few decades. Pathogenicity by this fungus is attributed to the production of host-selective toxins ( HST), which are recognized by their host in a genotype-specific...
- Resource Type:
- Article
- Full Text:
- GGG004044 41..63 INVESTIGATION Comparative Genomics of a Plant
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- Creator:
- Casey, Stephanie C., Vaccari, Monica, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Barcellos-Hoff, Mary Helen, Brown, Dustin G., Chapellier, Marion, Christopher, Joseph, Curran, Colleen S., Forte, Stefano, Hamid, Roslida A., Heneberg, Petr, Koch, Daniel C., Krishnakumar, P. K., Laconi, Ezio, Maguer-Satta, Veronique, Marongiu, Fabio, Memeo, Lorenzo, Mondello, Chiara, Raju, Jayadev, Roman, Jesse, Roy, Rabindra, Ryan, Elizabeth P., Ryeom, Sandra, Salem, Hosni K., Scovassi, A. Ivana, Singh, Neetu, Soucek, Laura, Vermeulen, Louis, Whitfield, Jonathan R., Woodrick, Jordan, Colacci, Annamaria, Bisson, William H., and Felsher, Dean W.
- Abstract:
- Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible carcinogens, the fields of endocrinology, genetics, epigenetics, medicine, environmental health, toxicology, pharmacology and oncology must be considered. Disruptive chemicals may also contribute to multiple stages of tumor development through effects...
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- Article
- Full Text:
- on the tumor microenvironment Casey, S. C., Vaccari, M., Al-Mulla, F., Al-Temaimi, R., Amedei, A
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- Creator:
- Buizert, Christo, Adrian, Betty, Ahn, Jinho, Albert, Mary, Alley, Richard B., Baggenstos, Daniel, Bauska, Thomas K., Bay, Ryan C., Bencivengo, Brian B., Bentley, Charles R., Brook, Edward J., Chellman, Nathan J., Clow, Gary D., Cole-Dai, Jihong, Conway, Howard, Cravens, Eric, Cuffey, Kurt M., Dunbar, Nelia W., Edwards, Jon S., Fegyveresi, John M., Ferris, Dave G., Fitzpatrick, Joan J., Fudge, T. J., Gibson, Chris J., Gkinis, Vasileios, Goetz, Joshua J., Gregory, Stephanie, Hargreaves, Geoffrey M., Iverson, Nels, Johnson, Jay A., Jones, Tyler R., Kalk, Michael L., Kippenhan, Matthew J., Koffman, Bess G., Kreutz, Karl, Kuhl, Tanner W., Lebar, Donald A., Lee, James E., Marcott, Shaun A., Markle, Bradley R., Maselli, Olivia J., McConnell, Joseph R., McGwire, Kenneth C., Mitchell, Logan E., Mortensen, Nicolai B., Neff, Peter D., Nishiizumi, Kunihiko, Nunn, Richard M., Orsi, Anais J., Pasteris, Daniel R., Pedro, Joel B., Pettit, Erin C., Price, P. Buford, Priscu, John C., Rhodes, Rachael H., Rosen, Julia L., Schauer, Andrew J., Schoenemann, Spruce W., Sendelbach, Paul J., Severinghaus, Jeffrey P., Shturmakov, Alexander J., Sigl, Michael, Slawny, Kristina R., Souney, Joseph M., Sowers, Todd A., Spencer, Matthew K., Steig, Eric J., Taylor, Kendrick C., Twickler, Mark S., Vaughn, Bruce H., Voigt, Donald E., Waddington, Edwin D., Welten, Kees C., Wendricks, Anthony W., White, James W. C., Winstrup, Mai, Wong, Gifford J., and Woodruff, Thomas E.
- Abstract:
- The last glacial period exhibited abrupt Dansgaard–Oeschger climatic oscillations, evidence of which is preserved in a variety of Northern Hemisphere palaeoclimate archives¹. Ice cores show that Antarctica cooled during the warm phases of the Greenland Dansgaard–Oeschger cycle and vice versa[superscript 2,3], suggesting an interhemispheric redistribution of heat through a mechanism...
- Resource Type:
- Article
- Full Text:
- A. Lebar8, James E. Lee1, Shaun A. Marcott1,22, Bradley R. Markle12, Olivia J. Maselli9, Joseph R
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- Creator:
- Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, and Young, Jasmine
- Abstract:
- Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
- Full Text:
- Workshop Paul D. Adams, Kathleen Aertgeerts, Cary Bauer, Jeffrey A. Bell, Helen M. Berman, Talapady N
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- Creator:
- Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, and Young, Jasmine
- Abstract:
- Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
- Full Text:
- ,2 Cary Bauer,3 Jeffrey A. Bell,4 Helen M. Berman,5,6 Talapady N. Bhat,7 Jeff M. Blaney,8 Evan