The mechanisms of substrate recognition by regulatory proteases are not well understood. Presently, two opposing models have arisen to describe E. coil Lon's ability to discriminate between substrates: one suggests the N-terminus involvement while the second suggests the C-terminus involvement. In this project, the role of the C-terminal domain as...
Over time, Open Source Software (OSS) has become indispensable in the creation and upkeep of software products, serving as the fundamental building block for widely used solutions in our daily lives, including applications that enable communication, entertainment, and productivity. A sustainable OSS ecosystem is one that attracts and retains a...
Metabolomics has recently gained momentum in biomolecule research and complements the genomics and proteomics research space. Metabolomics strives to detect, identify, and quantify all metabolites present in biological samples. In particular, biomolecular analysis using ultra-performance liquid chromatography combined with mass spectrometry (UPLC-MS) has become increasingly important for metabolomic analyses. Similarly,...
Constraining the magma evolution and dynamics that lead to the eruption of large volume continental arc systems is fundamental to our understanding of continental crust formation. An investigation into the magmagenesis that results in the formation of the Central Volcanic Zone (CVZ) in the Andes of South America, situated atop...
Pacific lamprey, Entosphenus tridentatus, have shown recent and rapid declines in abundance. These anadromous fish return to streams where they mature, spawn and die. It has been inferred that Pacific lamprey enter freshwater and reside for ~ 1 year before spawning. This long exposure to the freshwater environment may affect...