Mycobacterium abscessus (MAB) is an opportunistic pathogen responsible for infections in immunocompromised or immunosuppressed patients. Even with long-term treatment with multiple antibiotics, MAB pulmonary infections have high rates of treatment failure. Within the host, MAB is phagocytosed by key innate immune cells macrophages. The TLR2 and TLR4 are two critical...
Zoxamide is the sole β-tubulin inhibitor registered for the control of oomycete pathogens. The current study investigated the activity of zoxamide against Phytophthora sojae and baseline sensitivity was established with a mean EC₅₀ of 0.048 μg/ml. The data is critical for monitoring changes in zoxamide-sensitivity in the field. Three stable...
Full Text:
: 20 May 2016
doi: 10.3389/fmicb.2016.00762
Edited by:
Vijai Kumar Gupta,
National University of
Marine sediments are vast sources and reservoirs of methane, a potent greenhouse gas. Most of this methane is anaerobically oxidized by archaea before it can reach the overlying ocean, though the efficiency of this process often depends on methane fluxes and mechanisms of fluid transport. Anaerobic methanotrophic archaea, or ANME,...
Proteinaceous compounds are abundant forms of organic nitrogen in soil and aquatic ecosystems, and the rate of protein depolymerization, which is accomplished by a diverse range of microbial secreted peptidases, often limits nitrogen turnover in the environment. To determine if the distribution of secreted peptidases reflects the ecological and evolutionary...
Root-knot nematodes (Meloidogyne spp.) are one of the most important global plant pathogens. Recent innovations in molecular techniques have allowed increased study of this important pest, including the ability to investigate associated microbiomes. This study used 16S rDNA metagenomic sequencing to characterize the microbiome of Meloidogyne hapla, the northern root-knot...
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microbiome: looking back and future perspectives. Frontiers in Microbiology, 5. https://doi.org/10.3389/fmicb
Modulation of gene expression through RNA interference is well conserved in eukaryotes and is involved in many cellular processes. In the oomycete Phytophthora, research on the small RNA machinery and function has started to reveal potential roles in the pathogen, but much is still unknown. We examined Argonaute (AGO) homologs...
Important progress in understanding replication, interactions with host plants, and evolution of closteroviruses enabled engineering of several vectors for gene expression and virus-induced gene silencing. Due to the broad host range of closteroviruses, these vectors expanded vector applicability to include important woody plants such as citrus and grapevine. Furthermore, large...
Neisseria gonorrhoeae is an exquisitely adapted, strictly human pathogen and the causative agent of the sexually transmitted infection gonorrhea. This ancient human disease remains a serious problem, occurring at high incidence globally and having a major impact on reproductive and neonatal health. N. gonorrhoeae is rapidly evolving into a superbug...
The lagoons spanning Alaska’s Beaufort Sea coast provide a unique habitat for arctic wildlife. These lagoons and the food webs they support face extreme seasonality with nine months of ice cover followed by a spring thaw that pulses a large amount of freshwater and nutrients into the lagoons. Bacteria link...
Iron (Fe) and copper (Cu) are essential cofactors for microbial metalloenzymes, but little is known about the metalloenyzme inventory of anaerobic marine microbial communities despite their importance to the nitrogen cycle. We compared dissolved O₂ , NO₃⁻, NO₂⁻, Fe and Cu concentrations with nucleic acid sequences encoding Fe and Cu-binding...