Automation of computational chemistry, while only an engineering feat, has the potential to accelerating computational research be removing all by the science. The work in this thesis mainly discusses fundamental understanding of complex chemical systems. What is not obvious are the numerous tasks necessary for this fundamental understanding. Under the...
Pyroprocessing is an advanced technology for recycling used nuclear fuel. Pyrochemical processes encompass a wide range of chemical, physical, and electrochemical methods to partition fission products and other components from used nuclear fuel, which allows for the reuse of the actinides in nuclear fuel. This dissertation investigates two chemical systems...
Cutaneous melanoma remains the deadliest form of skin cancer arising from malignant transformation of pigment-producing melanocytes, with a diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. This DNA damage...
Despite the advance of biomedical science, infectious diseases remain one of the number one killers in the world. They claim the lives of millions of people annually, particularly in underdeveloped and developing countries. In fact, more than 32% of the health burden in Africa is caused by infectious diseases, e.g.,...
This study lays the groundwork on potential techniques that could be employed to improve the post-thaw wash processing of cryopreserved human red blood cells. Transfusion of red blood cells is one of the most commonly practiced procedures in clinical medicine. Millions of red blood cell units are transfused to patients...
In this work, three isomeric forms of N, N'-diethyl, N, N'-ditolyldipicolinamide (EtTDPA) were synthesized. The elements thorium through americium, which make up a significant portion of the actinides in used nuclear fuel (with the exception of curium), and two fission products, molybdenum and technetium, were tested for their ability to...
Pharmacokinetics (PK) is the study of the transit of drug into, within and removal from the body to reveal how the body acts on a drug when it is taken. There are four major areas in PK: absorption, distribution, metabolism and elimination. Pharmacokinetics research can be separated into two areas:...