The three studies that comprise this dissertation seek to answer significant
questions in paleoclimatology through unconventional applications of ice core
greenhouse gas data. These studies involve different gases and span the interval of time
between the Last Glacial Maximum and the Industrial Revolution, but are united by their
nontraditional use...
Full Text:
AN ABSTRACT OF THE DISSERTATION OF
Julia L. Rosen for the degree of Doctor of Philosophy in
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:
-us- l•l I Version 06
CLINICAL PROTOCOL APPROVAL FORM
Prot.x:ol Title:
Study No:
Cunent
Fungal hyphae are among the most highly polarized cells. Hyphal polarized
growth is supported by tip-directed transport of secretory vesicles, which accumulate temporarily
in a stratified manner in an apical vesicle cluster, the Spitzenkörper. The exocyst complex
is required for tethering of secretory vesicles to the apical plasma membrane. We...
Full Text:
plasma membrane during polarized growth
Riquelme, M., Bredeweg, E. L., Callejas-Negrete, O., Roberson, R
Successful host cell colonization by the Q fever pathogen, Coxiella burnetii, requires translocation of effector proteins into
the host cytosol by a Dot/Icm type 4B secretion system (T4BSS). In Legionella pneumophila, the two-component system (TCS)
PmrAB regulates the Dot/Icm T4BSS and several additional physiological processes associated with pathogenesis. Because PmrA...
Full Text:
Beare, P. A., Sandoz, K. M., Larson, C. L., Howe, D., Kronmiller, B., & Heinzen, R.
A. (2014
OBJECTIVES: Subclinical vascular disease (SVD) contributes to the aging process and may decrease life expectancy. We aimed to determine the contribution of gradations of SVD to the likelihood of achieving longer survival, and to determine what allows some individuals to achieve longer survival in the presence of high SVD.
DESIGN:...
Full Text:
Subclinical Vascular Disease Burden and Longer Survival
Odden, M. C., Yee, L. M., Arnold, A. M., Sanders, J
Air was sampled from the porous firn layer at the NEEM site in Northern Greenland. We use an ensemble of ten reference tracers of known atmospheric history to characterise the transport properties of the site. By analysing uncertainties in both data and the reference gas atmospheric histories, we can objectively...
Full Text:
. M. Trudinger5, E. Witrant6, J. L. Rosen7,
A. J. Orsi4, M. Rubino1,5, D. M. Etheridge1,5, L. P
The Last Interglacial (LIG) represents an invaluable case study to investigate the response of components of the Earth system to global warming. However, the scarcity of absolute age constraints in most archives leads to extensive use of various stratigraphic alignments to different reference chronologies. This feature sets limitations to the...
Full Text:
, J.S. Stoner h, F. Bassinot i, L. Bazin i, T. Blunier j,
N. Combourieu-Nebout k, A. El Ouahabi l, D
Invasions have increased the size of regional species pools, but are typically assumed to reduce native diversity.
However, global-scale tests of this assumption have been elusive because of the focus on exotic species richness,
rather than relative abundance. This is problematic because low invader richness can indicate invasion resistance by...
Full Text:
HAUT IER 1 , 7 , E R IC
L IND 1 , ANDREW MACDOUGALL 8 , JOHN L . ORROCK 9 , SUZANNE M . PROBER 1 0 , P
The use of in situ measurements is essential in the validation and evaluation of the algorithms that provide coastal water quality data products from ocean colour satellite remote sensing. Over the past decade, various types of ocean colour algorithms have been developed to deal with the optical complexity of coastal...
Full Text:
, N. Cherukuru4,
V. Brando4, A. Dekker4, L. Clementson4, A. C. Banks5,20, S. Maritorena6, P. J