Here we document introns in two Symbiodinium clades that were most likely gained following divergence of this genus
from other peridinin-containing dinoflagellate lineages. Soluble peridinin-chlorophyll a-proteins (sPCP) occur in short and
long forms in different species. Duplication and fusion of short sPCP genes produced long sPCP genes. All short and...
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Peridinin-Chlorophyll a-Protein Genes during Radiation of Symbiodinium (Dinophyceae) Clade A and B Lineages
As people encroach increasingly on natural areas, one question is how this affects avian biodiversity.
The answer to this is partly scale-dependent. At broad scales, human populations and biodiversity
concentrate in the same areas and are positively associated, but at local scales people and biodiversity are
negatively associated with biodiversity....
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., Radeloff, V. C., Lepczyk, C. A., Keuler, N. S.,
Wood, E. M., Stewart, S. I. and Hammer, R. B. (2014
Concentrations of polybrominated diphenyl ethers (PBDEs),
pesticides, polychlorinated biphenyls (PCBs), and polycyclic
aromatic hydrocarbons were measured in 136 fish from 14 remote
lakes in 8 western U.S. National Parks/Preserves between
2003 and 2005 and compared to human and wildlife contaminant
health thresholds. A sensitive (median detection limit, -18
pg/g wet...
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E Y
S I M O N I C H , * , † , § D A N C . K O C H , §
T A M A R A F . B L E T T , 4 C A R L B . S C
Greater scientific knowledge, changing societal values, and legislative mandates have emphasized the importance
of implementing large-scale flow experiments (FEs) downstream of dams. We provide the first global assessment
of FEs to evaluate their success in advancing science and informing management decisions. Systematic
review of 113 FEs across 20 countries revealed...
Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the
increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways
that could be responsible for rapamycin’s longevity effect,...
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in the Liver
Transcriptome
Wilson C. Fok1, Yidong Chen3,4,5, Alex Bokov2,3, Yiqiang Zhang2,6, Adam B
Ongoing greenhouse gas emissions can modify climate processes and induce shifts in ocean temperature, pH, oxygen
concentration, and productivity, which in turn could alter biological and social systems. Here, we provide a synoptic global
assessment of the simultaneous changes in future ocean biogeochemical variables over marine biota and their broader...
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, Jeroen Ingels13,14, Daniel O. B. Jones6, Lisa A. Levin10, Hideyuki Nakano15,
Karl Norling16, Eva Ramirez
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we
show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling
exclusively in intestine, and improves metabolic parameters in mouse models of obesity.
Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
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) regulates bile acid, lipid and glucose metabolism. Here we
show that treatment of mice with glycine-b
Coral reefs form vast ecosystems in tropical oceans that are hotspots for biodiversity and are economically valuable. The ecological success of coral reefs is made possible by the symbiotic relationship between corals and dinoflagellate algae from the family Symbiodiniaceae. In this symbiosis, the algae are found within host gastrodermal cells...
Objective: To examine the pricing trajectories in the United States of disease-modifying therapies (DMT) for multiple sclerosis (MS) over the last 20 years and assess the influences on rising prices.
Methods: We estimated the trend in annual drug costs for 9 DMTs using published drug pricing data from 1993 to...
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compared the cost trajectories for first-generation MS
DMTs interferon (IFN)–b-1b, IFN-b-1a IM, and
The Bend pumice and Tumalo tuff are products of a plinian eruption which occurred sometime between 0.89 and 2.6 m.y. The Bend pumice is a poorly consolidated, air-fall vitric lapilli tuff, which overlies a zone of reworked tephra. Perlitic obsidian in the reworked zone probably represents the remains of a...
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a strong negative Eu anomaly in the B-T
rhyodacite further indicates that the Bend pumice and