Autophagy, a homeostatic degradation pathway, has a role in promoting cell survival under stress conditions, but can also promote cell death under conditions of sustained stress. This project investigates the cytotoxic potential of coibamide A and other natural products in autophagy-deficient and wild-type mouse embryonic fibroblasts (MEFs). Wild-type MEFs were...
Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...
EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
The study of nonlinear vibrations of systems having two
degrees of freedom has met considerable attention during the past
few years. Nonlinear symmetrical systems have received most of it.
Normal mode motion of a system is defined as a periodic motion
such that the masses of the system assume repeated...
A mechanism is a constrained kinematic chain composed of
gears, links, cams, or the like. Mechanisms are the building blocks
of all machines, and, as such, their evaluation is of considerable
importance to the mechanical designer. Because the mathematical
analyses of systems with four or more moving members has been...
These studies are concerned with the forced motion of a two-degree-of-freedom system consisting of a "flexible beam" supported
by pendulum type hangers.
Using an asymptotic method, an approximate solution to the
nonlinear equations of motion was found. The solution takes the form
of a series in powers of the amplitude...
This thesis deals with the effect of pressure coupling on the
stresses in shells having geometric discontinuities. The problems
are, 1) cylinder with an axially symmetric thickness change and
2) cylinder with a hemispherical end closure. Solutions to the
above problems are based on differential equations that included the
straightening...
A model for analytical study of the attitude stability of an
orbiting satellite consists of a rigid body whose mass center is constrained to move at constant speed in a circular path about the
center of an inverse-square force field. The body is assumed to
have one axis of inertial...