In their modern context questions of heredity have come to be
closely aligned with theories of evolution because all such theories
require the presence of heritable variation. Thus the need for an
understanding of a source of variation and a mechanism for its inheritance
became very apparent with the general...
This analysis concerns the life and scientific work of Henry
Augustus Rowland (1848-1901), organizer and the first chairman of
the physics department at The Johns Hopkins University in 1876.
Special materials used in this research included three pieces of
Rowland's experimental apparatus which are extant in the Smithsonian
Institution Division...
7,7'-Dihydroxy-8,8'-biquinolyl (azaBINOL) was prepared from 7-hydroxyquinoline via N,N-dimethyl O-quinol-7-yl carbamate by directed ortho-metallation followed by FeCl₃-mediated oxidative coupling of the 8-lithioquinoline intermediate. Saponification of the resulting dicarbamate provided crystalline (±)-azaBINOL in 56% overall yield. 6,6'-Bis(dimethylaminocarbonyl)-7,7'-dihydroxy-8,8´-biquinolyl was prepared from the same dicarbamate by a double anionic-Fries rearrangement in 43% yield. 7,7'-Bis(diethylamino-carbonyloxy)-6,6'-diiodo-8,8´-biquinolyl...
In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health.
The first case study investigated...
Ambifunctional axially chiral 2,2',6,6'-tetrasubstituted biphenyls containing nucleophilic (or basic) functional groups juxtaposed with hydrogen-bond donors were synthesized and their properties studied. Applications for the prepared biaryls as potential organocatalysts for enantioselective carbon-carbon bond forming reactions were examined. Processes investigated included: aldol, Michael, nitroaldol (Henry), and Baylis-Hillman reactions.
The novel amidoamine...
Prior to World War One, plastic surgery, as in its present form, was yet unfounded and not recognized as a genuine medical specialty. The carnage of the war prompted Britain to establish a specialized treatment center for plastic surgery, first at Aldershot and then at Sidcup, under the leadership of...
The publication of Charles Darwin’s On the Origin of Species, truly a synthesized work of natural history, coincided with the emergence of specialized disciplines in the 19th century. This thesis aims to explore the relationship between the specialization of knowledge, in the form of disciplinization, and the reception of new...
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Paul Lawrence Farber Mina Carson
The publication of Charles Darwins On the Origin
Siletz Bay is a drowned river valley filled with Holocene alluvial
and estuarine sediments and is separated from the ocean by a sand
spit 3.8 km in length. Since the area was settled by white man in the
1890's, the bay has apparently experienced rapid siltation, due to
increased farming...
Cannabis sativa L. is emerging as an economically important crop, particularly for its high levels of cannabinoid production. One of these cannabinoids, cannabigerolic acid (CBGA), is the precursor to many well-researched cannabinoids such as the psychotropic delta-9-trans-tetrahydrocannabinolic acid (Δ9-THCA i.e., THCA) and the medically relevant cannabidiolic acid (CBDA). CBGA has...