Human liver cancer is one of the deadliest cancers worldwide, with hepatocellular carcinoma (HCC) being the most common type. Aberrant Ras signaling has been implicated in the development and progression of human HCC, but a complete understanding of the molecular mechanisms of this protein in hepatocarcinogenesis remains elusive. In this...
There has been a tremendous growth in interest in carbon nanodots (C-dots) in the past several years. As a nascent nanomaterial, C-dots have shown great promise in applications that benefit from their superior water dispersibility, low toxicity, non-blinking fluorescent output, chemical and biological compatibility, ease of functionalization and resistance to...
Quaking aspen (Populus tremuloides Michx) is a species with high phenotypic plasticity and a broad distribution that, in the last decade, has experienced climate stress-induced mortality called Sudden Aspen Decline (SAD). In order to help mitigate the effects of SAD in the future, we need a better understanding of aspen’s...
The hydrophobicity of soils of the Deschutes National Forest was
studied. The soils are Cindery Typic Cryorthents, formed in cinders
and ash from Mt. Mazama. Ponderosa pine is the dominant overstory
vegetation. Of particular interest was the effect of prescribed
burning on hydrophobicity. Fire has been shown to cause a...
"It appears that the summer of 2003 was very likely warmer than any other
summer in Europe back to 1500" (Luterbacher, 2004). This was the conclusion of a
study about the changing climate of Europe by climatologists at the University of
Bern, Switzerland, and published in Science in May, 2004....
In this report, three studies are presented that utilize computations to predict transformations, identities, and properties of environmental organic molecules. Each study shows how computations can lead to models of chemical behavior. The importance of this research is rooted in the need for understanding how human behavior and health intersect...
The Cretaceous was a period of extreme climatic conditions accompanied
by major perturbations in ocean-atmosphere biogeochemical cycles. One of the
most intriguing features is the sporadic interruption of normal marine pelagic
sediment deposition by organic rich sediments deposited during oxygen-deficient
conditions (ocean anoxic events OAEs). A current model for the...
More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...