The methodology to perform bioequivalence studies for prodrug products has not been finalized by FDA leaving the investigators to speculate over the proper approach. This study innovatively utilized the bootstrap methods for testing in vivo bioequivalence on both parent drug and metabolite of four prodrug products: Clopidogrel, Prednisone, Allopurinol, and...
The International Commission on Radiological Protection (ICRP) has modeled twelve reference animal and plant (RAP) species using simple geometric shapes in Monte–Carlo (MCNP) based simulations. The focus has now shifted to creating voxel phantoms of each RAP to advance the understanding of radiation interactions in nonhuman biota. The work contained...
The occurrence of two wildfires separated by 31 yr in the chaparral-dominated Arroyo Seco watershed (293 km²) of California provides a unique opportunity to evaluate the effects of wildfire on suspended-sediment yield. Here, we compile discharge and suspended-sediment sampling data from before and after the fires and show that the...
Researchers rely on bioeconomic models to guide research and generate fishery management advice for commercial fisheries. Due partly to a paradigm shift towards ecosystem based fishery management, increasing complexity in the characteristics of the problems has meant that bioeconomic simulation models are becoming more prevalent in the fisheries literature. However...
The Thurstone-Mosteller and Bradley-Terry Models are commonly used to rank items from paired comparisons experiments in which one item in each pair "wins," and to assess the importance of time-independent explanatory variables on such rankings. The first part of this thesis clarifies the use of probit and logistic regression models...
In this dissertation, the structure and electronic properties of multiple metal oxide thin films are characterized and presented. Prompt inorganic condensation (PIC) of metal-oxo and –hydroxo clusters was evaluated as a technique for making metal oxide clusters in two separate studies. The first focuses on the synthesis of lithium niobate...
Published September 2002. Reprinted May 2006. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
In this dissertation we consider two application specific flow and transport models in porous media at multiple scales: 1) methane gas transport models for hydrate formation and dissociation in the subsurface under two-phase conditions, and 2) coupled flow and biomass-nutrient model for biofilm growth in complex geometries with biofilm, and...
The relative success of restoration practices on cheatgrass infested sagebrush steppe lands in the Great Basin can affect the probability of crossing an ecological threshold and have economic effects on cattle ranches using federal rangelands. Cheatgrass invasion implies an increase in the risk of fire, which in turn increases the...
Presented at 2009 Institutional Repositories: Disseminating, Promoting, and Preserving Scholarship Conference held September 30 at Utah State University in Logan, Utah.
Abalone, Haliotis asinina, is a high value shellfish for export trade that provide cash income to fishing households in some coastal communities in the Philippines. Stock enhancement is one of the fisheries management strategies that enable recovery of overfished stocks through release of juveniles and consequent stock increase through recruitment....
This compilation of theses and dissertations (a part of the OSU Bibliographic Series) for the period 1970-1977 reflects this university's emphasis on research and graduate study. It may be viewed as an indicator of the contributions made to the state of Oregon through graduate study and research at Oregon State...
This thesis discusses both theoretical and practical considerations inherent in conducting community-based research within a case study of sea turtle conservation in Baja California, Mexico. A brief background, including the general ecology, status and distribution of sea turtles of the Baja peninsula is presented, with an overview of the current...
SUMMARY - REASONS FOR PERFORMING STUDY: Exertional rhabdomyolysis (ER) is a reported syndrome in competing endurance horses; however the prevalence and cause of ER in this population has not been defined.
OBJECTIVES: To determine the prevalence of ER in a sample of endurance racing horses, and to investigate factors, including...
La présente étude, sur les caractéristiques adaptatives des populations vivant de la pêche artisanale, fut menée au cours de l'été 1994 dans la région lagunaire-estuaire Iguape-Cananéia, située dans le sud-est brésilien. L’auteur démontre que contrairement à une vision statique de la pêche artisanale, ces populations se caractérisent par un forte...