Photoactivated biomedical tools like fluorescent biosensors and optogenetic proteins have increased in popularity due to the precision targeting and activation used for in vivo applications. In nature, the initially discovered parent proteins exhibit properties such as fluorescence quantum yield (FQY), fluorescence color, and photoswitching dynamics that are unfavorable in mammalian...
The purpose of this exploratory study was to develop an instrument to measure perceived food autonomy (PFA) among cognitively alert residents in state licensed Assisted Living (AL) facilities, and to investigate the influence of PFA on food satisfaction, while controlling for functional (physical, social, and psychological) status, general health, and...
This dissertation presents nonlinear terahertz (THz) properties of carbon nanomaterials investigated by time-resolved high-field THz spectroscopy. In order to determine THz characteristics of nanomaterials, we performed THz power spectrum measurement, THz raster imaging, THz time-domain spectroscopy (THz-TDS) and time-resolved pump-probe experiment on two different types of single layer graphene and...
The goal of this study was to develop an understanding of the nature of surge wave loading on
wood framed residential structures for a variety of building configurations and test conditions.
The objectives of the study were: (1) to measure forces on a 1/6th scale wood framed
residential structure, (2)...
Sotalol is a class III anti-arrhythmic drug with class II properties that is commonly used in the treatment of ventricular tachyarrhythmias in dogs. The anti-arrhythmic effects of sotalol are mediated by an increase in action potential duration and prolongation of atrial and ventricular repolarization via antagonism of the delayed rectifier...
In this dissertation, excited state proton transfer (ESPT) and its inhibition in solution and protein environments are revealed using both femtosecond transient absorption (fs-TA) spectroscopy and femtosecond stimulated Raman spectroscopy (FSRS). Using a tunable Raman pump to enhance transient vibrational features of the photoacidic chromophore HPTS in methanol and methanol...
Femtosecond stimulated Raman spectroscopy (FSRS) is a powerful ultrafast technique which can track photoinduced excited state structural events on femtosecond (fs) to picosecond (ps) timescales. In addition to high temporal and spectral resolutions, FSRS provides a broad spectral window from ca. 100—2000 cm-1 for detection, enabling the direct mapping of...
During the Canterbury Earthquake Sequence (CES) in Christchurch, NZ, an estimated $15B in damages occurred due to liquefaction-induced phenomena, illustrating the importance of understanding site-specific responses to seismic ground motions, as well the importance of accurately predicting liquefaction severity. One potential method for improving the understanding of how a site...
Gene transfer via interspecific hybridization within Phaseolus has
been limited by abnormal hybrid development and the rapid loss of
hybridity in subsequent generations. The most advanced embryo
development occurs in P. vulgaris x P. coccineus where mature seeds
form. However, the reciprocal cross still results in abnormal embryos
unable to...
As CMOS processes keep scaling down devices, the maximum operating frequencies of CMOS devices increase, and hence circuits can process very wide band signals. Moreover, the small physical dimensions of transistors allow the placing of many more blocks into a single chip, including highly accurate analog blocks and complicated digital...