Studies toward the total syntheses of highly potent cytotoxic alkaloids
including the bromopyrrole alkaloids and indole alkaloids were conducted and are
described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...
An alternative metric for assessing nearshore hydrodynamic impact due to Wave Energy Converter (WEC) arrays is presented that is based on the modeled changes in alongshore radiation stress gradients in the lee of the array. The metric is developed using a previously observed relationship between measured radiation stresses and alongshore...
Radiation stresses, defined as the excess flow of momentum due to the presence of waves (Longuet-Higgins, 1964), are the main drivers behind the cross-shore and longshore forcing that results in wave setup, set-down, and longshore currents (e.g. Svendsen, 2006). Longshore currents entrain and transport sediment and therefore play an important...
In this study, the effects of implementing different wind input or physics packages in a numerical wave model to recreate large wave conditions are explored. Three large wave events are simulated with WaveWatch III. The wind inputs which are compared are NCEP's Global Forecasting System (GFS) with 0.5 degree resolution...
Estuaries represent the confluence of land and ocean environments and encompass a number of complex interactions amongst tides, winds, offshore waves and the riverine contributions, all of which contribute to total water levels (TWLs). The study of TWLs and the relative weight of its components can assist local communities in...
Wave energy has the potential to power large and small factions of economies around the world alike. Current methods for determining the amount of wave energy resource available to wave energy converter (WEC) devices entail capturing the look of the sea state at large by presenting characteristic wave heights, periods,...
BACKGROUND: On the basis of the 2014 guidelines for hypertension therapy in the United States,
many eligible adults remain untreated. We projected the cost-effectiveness of treating
hypertension in U.S. adults according to the 2014 guidelines.
METHODS: We used the Cardiovascular Disease Policy Model to simulate drug-treatment and
monitoring costs, costs...
Coastal flood hazard zones and the design of coastal defenses are often devised using either the maximum recorded total water level (TWL) or a 'design' event such as the 100-year return-level flood, usually projected from observed extreme events. Despite technological advances driving more consistent instrumental records of wave heights and...
Wave runup is an important physical process that affects nearshore sediment transport, coastal erosion, and flooding. Large and unexpected runup events can also be dangerous to beach goers. Extreme runup statistics are essential parameters used in engineering design of marine structures and in coastal management. Although the study of runup...
The concept of reducing laboratory operations into microfluidic devices has been an attractive area of research for several decades. Due to several advantages of porous-media microfluidic devices including low mass, portability, power-free fluid transport, and the ability to store dried reagents in the porous structures, these devices show great promise...