The development of new technologies in science is a balance between existence and use. There are three versions of this duality – something is built and users come, something is built and users don’t come, and, finally, potential users show up but the ballpark has not yet been built. In...
Studies towards the total synthesis of (−)-kendomycin (1), a bacterial metabolite with
a unique molecular architecture and pronounced biological activity, are described. These
studies resulted in the synthesis of advanced intermediate 208, containing all of the
carbon atoms of 1.
A Dötz annulation between alkyne 122 and novel chromium carbenoid...