The end of the Cold War brought about changes within international political relations that resulted in expanded interest in global civil society. Such developments, like globalization and democratization, have encouraged the growth of social and political organizations. Political scientists have found that these inter-governmental and non-governmental organizations have a significant...
Two specific goals were addressed for this dissertation. First to investigate and identify the mechanistic profile of ketoconazole (KT)-induced hepatotoxicity by utilizing in vivo and in vitro approaches determining the mechanism of action for the hepatotoxicity incurred. To date, there has not been a mechanistic determination of the hepatotoxicity associated...
Rubus seed characteristics; seed coat morphology, anatomy, germination requirements and dormancy were studied in order to define protocols for breaking seed dormancy. Morphological analysis of the seed coat (testa) using scanning electron microscopy (SEM) included 56 seed accessions of 10 subgenera preserved in the collections of the US Department of...
Through examination of empirical evidence on individuals with Asperger’s Syndrome and related Pervasive Developmental Disorders, the author attempts to provide an overview of the social deficiencies associated with these disorders. Points of primary concern are the social deficiencies in developing competence in experience-sharing and demonstrating empathy, especially in how they...
Three types of experiments were designed to further characterize
the tryptophan decarboxylating enzyme of Reed and Crecelius
(1967).
1) Light inhibition studies were made with etiolated pea seedlings
to determine the in vitro response of the tryptophan decarboxylating
enzyme. Assays of indoleacetic acid oxidase (IAA oxidase)
and guaiacol-active pea seedling...
The rate of the C¹⁴0₂ release from glucose, specifically labeled
with C¹⁴ at 1, 2, 3+4, and positions, was used to study the relative
participation of pathways of glucose catabolism in red beet slices.
Evidence was obtained which indicated that in mature red beets glucose
was catabolized mainly via glycolysis-tricarboxylic...
Several aspects of the potent inhibition of bovine plasma amine
oxidase (PAO) by hydrazines were investigated by kinetic and preparative
means. The inhibition was classified as pseudo-irreversible
by the method of Ackerman and Potter (Proc. Soc. Exptl. Biol. Med.
72, 1 (1949), and was found to exhibit Zone B kinetic...
Recent studies have demonstrated that perturbations of
intracellular thiol and calcium homeostasis may be important events
in the early development of cell injury by toxic chemicals.
Incubation of isolated rat hepatocytes in a calcium free
medium, severely depleted intracellular Ca²⁺ levels and resulted in
the loss of both cytosolic and...