Previous investigation showed that 20 mg/kg BCNU
caused inhibition of sulfobromophthalein (BSP) excretion
and inhibited bile salt independent bile flow (BSIF) in
rats by 48 h after treatment (Hoyt, 1984).
The present investigation demonstrated that BCNU
inhibited the canalicular step in the excretion of BSP.
This was indicated by the...
Glutathione, a ubiquitous intracellular tripeptide, protects cells by reacting with electrophiles and radicals that can damage cellular macromolecules. However, glutathione conjugation is now recognized as one mechanism by which drugs and xenobiotics can also be converted to reactive intermediates having toxic consequences to cells. The halogenated alkane 1,2-dichloroethane forms S-(2-chloroethyl)...
Papain-like leader proteases are found in diverse families of human, animal, plant, and fungal positive-strand RNA viruses. In addition to autocatalytic processing, these proteases play a variety of roles in the virus life cycle. In particular, the leader protease (L-Pro) of a prototype member of the Closterovirus genus, Beet yellows...
The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...
This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...
This chapter is divided into three main sections. The first section discusses land cover map development. It begins by providing background information on the regional division of labor and the regional land cover legend. It then focuses on our land cover mapping methods, including a description of data sources, the...
Reflux condensation tests examining steam condensation in a PWR steam generator (SG) were conducted at the Oregon State University (OSU) Advanced Plant Experiment (APEX) Test Facility from 2005 through 2007. The experimental data collected will provide a basis to assess TRACE steam generator modeling techniques and assist in development of...
Birth and pupping season records of Pacific harbor seals
(Phoca vitulina richardsi) were used in an analysis of
photoperiod effect on the timing of birth in this species. Dates
and latitudes of births were converted into photoperiods using a
photoperiod equation. Sequential dates from parturition were
converted into photoperiods and...