Iron (Fe) and copper (Cu) are essential cofactors for microbial metalloenzymes, but little is known about the metalloenyzme inventory of anaerobic marine microbial communities despite their importance to the nitrogen cycle. We compared dissolved O₂ , NO₃⁻, NO₂⁻, Fe and Cu concentrations with nucleic acid sequences encoding Fe and Cu-binding...
In recent decades, the occurrence of large, high severity wildfires has increased substantially in many parts of the world, including the western United States. These fires have the potential to impact water quality, aquatic ecosystems, and downstream communities for many decades. As such, it is increasingly important to understand the...
Work engagement is demonstrated when employees are involved with, committed to,
enthusiastic, and passionate about their work. The goal of this study was to summarize
relevant information on work engagement, produce a working coding system to identify
evidence of work engagement, and discuss the implications of work engagement on an...
The psychoactive component of marijuana, A9-tetrahydrocannabinol (THC), is known
to have effects in humans that are mediated by the cannabinoid receptor (CB 1). Although a great deal of research has been done to confirm the interaction of exogenous cannabinoids with the CB 1 receptor, little is known about the receptor's...
Current natural product (NP) research is limited by its reliance on bioassay-guided fractionation to identify bioactive compounds in mixtures. Computational approaches may improve NP research by correlating mass spectra (MS) and nuclear magnetic resonance spectra (NMR) of bioactive mixtures to their bioactivity patterns. In this study, I use artificial neural...
The extent and severity of wildfires in forested regions are increasing throughout many regions on the planet, including western North America. High-severity wildfires directly affect soils and vegetation by altering soil hydraulic properties, reducing soil organic matter, exporting carbon and nitrogen, and killing trees and understory vegetation. These impacts can...
The 3-substituded indolic enamide moiety has been found in many marine compounds over the past 20 years. These indolic enamides exhibit various biological properties such as cytotoxic, anthelmintic, antimicrobial and HW-inhibitory activities. Among these indolic enamides, some are (E)-enamides, like coscinamide A and coscinamide B, others are (Z)-configuration in their...
Studies toward the total syntheses of highly potent cytotoxic alkaloids
including the bromopyrrole alkaloids and indole alkaloids were conducted and are
described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...
Shallow subsurface flow and surface runoff are spatially and temporally variable in forested environments. The location and timing of this runoff depends on both site characteristics (e.g., vegetation, soil texture, geology, and topography) and on time-varying conditions (e.g., soil water content, precipitation type, duration, magnitude, and intensity). Forest management activities...