The Cascadia subduction zone has been characterized as a typical Chilean-type
subduction zone based on qualitative comparisons of plate age and convergence rate, with
simple forearc structure. However, the discovery of unusual structural styles of
deformation, variations in the morphology of the forearc, and its absence of seismic activity
suggest...
This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...
Legislation can be an effective public health tool, and understanding the factors that influence legislative outcomes is advantageous for public health practitioners who propose and advocate for legislation. The literature indicates that the issues of personal freedoms, the presence or absence of strong coalition leadership, and political conditions and ideology...
The climate of the Pacific Northwest is in flux, and existing forest ecosystems are stressed and poised to shift in fundamental ways, with or without human intervention. This dissertation probes the nature of forest responses to environmental change through investigations of morphology and genetics of three species of alder co-occurring...
Nutrigenomics is a branch of nutrition that seeks to elucidate the relationship between dietary components and expression of genes. Certain bioactive compounds present in the diet have the potential to modulate transcription of genes through their interactions with ligand-dependent nuclear receptors, a series of transcriptional regulators capable of sensing intracellular...
A globally integrated carbon observation and analysis
system is needed to improve the fundamental understanding
of the global carbon cycle, to improve our ability to
project future changes, and to verify the effectiveness of policies
aiming to reduce greenhouse gas emissions and increase
carbon sequestration. Building an integrated carbon observation...