Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
Full Text:
, James C, Josefsson EC et al.
Deciphering the molecular and biological processes that mediate histone
The influence of irrigation frequency (same amount of water per day given at different times) and nitrogen (N) fertilizer rate on water stress [stomatal conductance (gs)], N uptake, and growth (biomass) of container-grown evergreen Rhododendron 'P.J.M. Compact' and 'English Roseum' and deciduous Rhododendron 'Gibraltar' was evaluated. Both N deficiency and...
Litter decomposition is a keystone ecosystem process impacting nutrient cycling and productivity, soil properties, and the terrestrial carbon (C) balance, but the factors regulating decomposition rate are still poorly understood. Traditional models assume that the rate is controlled by litter quality, relying on parameters such as lignin content as predictors....
Full Text:
.
www.pnas.org/cgi/doi/10.1073/pnas.1508945112 PNAS | Published online September 8, 2015 | E5253–E5260
EC
O
LO
Coastal Oregon is deficient in quality construction aggregate.
There is, however, an abundance of lower quality, or marginal aggregate
available for construction purposes. The purpose of this report
is to develop techniques for upgrading marginal aggregates with portland
cement and methods for evaluating the relative performance of
these stabilized materials...
The Hawaiian-Emperor seamount chain is the ‘‘type’’ example of an age-progressive, hot spotgenerated intraplate volcanic lineament. However, our current knowledge of the age distribution within this province is based largely on radiometric ages determined several decades ago. Improvements in instrumentation, sample preparation methods, and new material obtained by recent drilling...
We hypothesized that calpain activity is elevated in response to muscle damage. To test this hypothesis, we examined the degradation of α-fodrin into its 150 and 145 kDa fragments following either 20 eccentric or isometric contractions. In addition, experiments were performed in the presence or absence of E-64-d, a calpain...
Many bacteria possess cell density-dependent quorum-sensing (QS) systems that often regulate cooperative secretions involved
in host-microbe or microbe-microbe interactions. These secretions, or “public goods,” are frequently coregulated by stress and
starvation responses. Here we provide a physiological rationale for such regulatory complexity in the opportunistic pathogen
Pseudomonas aeruginosa. Using minimal-medium...