TAC is the most commonly used medication in post transplantation maintenance immunosuppression therapy. TAC lipophilicity and its erratic oral absorption especially in the presence of food intake result in great intra- and interpatient pharmacokinetic variations. Complicated dosing and frequent required therapeutic monitoring is thought to be the main cause of...
Cryopreservation of adherent cells may be advantageous for cell types that are difficult to
preserve in suspension or when it is necessary to preserve characteristics of the adherent cultured cells. Vitrification is a promising procedure for the preservation of adherent cells that prevents ice crystal formation and the resulting dissociation...
Soil bulk density and disturbance were measured before and after a commercial
thinning of 3 0-50 year-old Douglas-fir using a cut-to-length (CTL) and a skyline system
on the Willamette National Forest in the Oregon Cascades. A dual-probe nuclear
densimeter was used to measure bulk density at four and eight inches....
In the last decade, there has been renewed interest in the use of granulocyte transfusions to treat infections in individuals with compromised immune systems. However, granulocytes only remain functional for about a day after isolation and this short shelf life is a significant drawback. Cryopreservation would allow long term storage...
Semi-volatile trace metals (e.g., Cd, Sn, Pb, Zn, Cu, Mo) have been analyzed by using laser ablation ICP-MS in a number of silicate glasses (GSE-1G, GSD-1G, NIST 610, NIST 612, BCR-2G, BHVO-2G). Our work investigates and highlights sources of uncertainty in the analysis of semi-volatile metals using LA-ICP-MS. We identify...
Tacrolimus is an immunosuppressant drug approved by the FDA for the prevention of organ transplant rejection. However, the use of this drug is hindered by its narrow therapeutic window and extreme insolubility in water. Due to these properties, the currently used tacrolimus preparations must be administered once or twice daily...
The Tam McArthur Rim is a volcanic center located within the Tumalo Volcanic Field (TVF), approximately 25 km west of Bend, OR. The rim comprises of shallowly dipping bedded sequences of intermediate and silicic flows with minor tephra interbedding capped by a rhyodacite dome. Glacial activity has exposed significant portions...
This study examined the effects of timber harvest and subsoiling on soil physical properties considered important to forest productivity and hydrologic concerns. Ground based mechanical timber harvesting on some soil types can cause soil disturbance including compaction. These effects in turn can influence multiple important soil physical properties that affect...
Spray drying has been widely used in food science for long-term storage of products such as powdered milk, and it has recently been used for preservation of more temperature sensitive products such as human blood plasma and single-cell organisms. However, there are no previous reports of successful spray drying of...
Several different petrological techniques have been applied to lava flows between
200 to 475,000 years old from Mount Hood, Oregon. Mount Hood is unusual, in comparison to nearby Mount St. Helens and Mount Jefferson, in that it has produced relatively homogeneous lava compositions over 475,000 years. Erupted lavas are mostly...