Glutathione, a ubiquitous intracellular tripeptide, protects cells by reacting with electrophiles and radicals that can damage cellular macromolecules. However, glutathione conjugation is now recognized as one mechanism by which drugs and xenobiotics can also be converted to reactive intermediates having toxic consequences to cells. The halogenated alkane 1,2-dichloroethane forms S-(2-chloroethyl)...
A fish sampling program was initiated at Cottage Grove Reservoir
in June of 1974 to investigate mercury accumulation in the fish.
Samples were collected periodicallv from June to November, 1974, and
from June, 1975 through January, 1976 from both the reservoir and its
tributaries. Species collected included spring chinook salmon...
The purpose of the thesis is to design, construct,
program, and test an automatic integrated circuit test
system. The class of integrated circuits tested was restricted
to digital integrated circuits. The general concept
of testing a digital integrated circuit is based on
the truth table of that circuit. A combination...
In regression analysis, random errors in an explanatory variable cause the
usual estimates of its regression coefficient to be biased. Although this problem has
been studied for many years, routine methods have not emerged. This thesis
investigates some aspects of this problem in the setting of analysis of epidemiological
data....
The behavioral repertoire of the sea anemone, Anthopleura
xanthogrammica, was investigated to test for the occurrence of any
immediate response to various regions of the electromagnetic spectrum.
Monochromatic radiations in the visible and ultraviolet spectral
regions were produced by a 150-watt xenon lamp or a ZOO watt mercury
vapor lamp...
Senecio jacobaea (tansy ragwort) is a common weed in the
Pacific Northwest that contains toxic pyrrolizidine alkaloids
(PAs). Jacobine, the major PA in Senecio jacobaea, was incubated
with rat liver microsomes and metabolites were isolated by high
performance liquid chromatography (HPLC) and identified by mass
spectrometric analysis. Metabolites included a...
Nonalcoholic fatty liver disease (NAFLD) is characterized by an accumulation of neutral lipids in the form of triglycerides and cholesterol esters accounting for >5% of liver weight. Excess neutral lipids accumulate in large lipid droplets, i.e., macrosteatosis, displacing the nucleus of cells. Current theory suggests neutral lipid accumulation is the...
In order to determine the total number of cytochrome P-450 isozymes
present in a given species following various treatments, mature
male rats (Sprague-Dawley) were injected intraperitoneally with the
classic mixed-function oxidase inducers phenobarbital (PB), pregnenolone-
16a-carbonitrile (PCN), 3-methylcholanthrene (3-MC), or the appropriate
control vehicle.
Hepatic microsomes were solubilized and P-450...
The Aleutian tern (Onychoprion aleuticus) is a species of high conservation concern in Alaska due to large declines at known breeding locations since the 1960s. Due to the small population size and ephemeral behavior of this species on the nesting grounds, there is little basic biological information available and data...