With Alzheimer’s disease being the most prominent form of dementia, finding potential treatments for the disease is imperative. This study explored the non-steroidal anti-inflammatory drug ibuprofen as a potential treatment to normalize the hyperactive N-methyl-d-aspartate receptor (NMDAR) within the 5xFAD mice early in the disease pathology before cognitive decline. Female...
Electricity is a vital energy source for modern life, and is used in almost every aspect of daily life. United States electricity consumption totaled nearly 3,886,403 gigawatt hours in 2011. Residential electricity consumption accounts for 37 percent of total electricity consumption in the United States. Between 1990 and 2007, the...
The role of glaciers as temporal water reservoirs is particularly pronounced in the (outer) tropics because of the very distinct wet/dry seasons. Rapid glacier retreat caused by climatic changes is thus a major concern, and decision makers demand urgently for regional/local glacier evolution trends, ice mass estimates and runoff assessments....
We describe an integrated spatially distributed hydrologic
and glacier dynamic model, and use it to investigate
the effect of glacier recession on streamflow variations
for the upper Bow River basin, a tributary of the South
Saskatchewan River, Alberta, Canada. Several recent studies
have suggested that observed decreases in summer flows...
This dissertation addresses issues of strategic behavior of firms in oligopoly markets. In the first study we analyze how generic advertising affects brand advertising and firm profits in differentiated oligopoly markets. We develop two models, one with vertical differentiation and another with horizontal differentiation. In the case of vertical differentiation,...
The ever-increasing global population presents looming problems for the field of agriculture. Global food demand will, at some point, increase to the point where there is not enough crop-ready land to keep up. This creates an additional incentive, other than economics, for growers to increase their yield-per-acre and make sure...
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...
Every country has its own unique culinary heritage that has developed over time and that has led to specific eating behaviors, eating patterns, and attitudes toward food. In this thesis, I aim to answer a central question: how have the culinary histories of France and the United States shaped their...
The marked increase in surface-to-volume ratio associated with microscale devices for hemodialysis leads to problems with hemocompatibility and blood flow distribution that are more challenging to manage than those encountered at the conventional scale. In this work, stable surface modifications with pendant polyethylene oxide (PEO) chains were produced on polycarbonate...
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Joseph McGuire
The marked increase in surface-to-volume ratio associated with