Identification of new molecular targets for the treatment of breast cancer is an important clinical goal, especially for triple-negative breast cancer, which is refractory to existing targeted treatments. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known primarily as the mediator of dioxin toxicity. However, the AhR can...
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, Yamamoto M, Fujii-KuriyamaY et al.
A constitutively active arylhydrocarbon receptor induces growth
The mechanism(s) involved with intrauterine migration of the porcine embryo was investigated. Twenty-four gilts on Days 6, 9 and 12 of gestation (Day 0 = 1st day of estrus) were utilized to examine the relationship between myometrial activity and intrauterine migration. On Day 2, embryos were flushed from one oviduct...
Genetic and environmental factors influence individual cancer risk. Mutations in DNA mismatch repair (MMR) genes increase colon cancer risk. Exposure to carcinogens, including the ubiquitous polycyclic aromatic hydrocarbons (PAHs), also is associated with increased cancer risk. To understand the combined effects of both environmental exposures and genetic risk, we investigated...
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software is
used to plot the number of cells (y-axis) against the intensity of PI fluorescence (x-axis
A large number of river otter (Lontra canadensis) males were collected
from areas of high and low contaminant concentrations throughout western
Oregon and Washington during the fall and winter of 1994-99. Few significant
non-reproductive organ morphometric differences were found in the large series
of male otters collected, except for adrenal...
A large number of river otter (Lontra canadensis) males were collected
from areas of high and low contaminant concentrations throughout western
Oregon and Washington during the fall and winter of 1994-99. Few significant
non-reproductive organ morphometric differences were found in the large series
of male otters collected, except for adrenal...
Reproductive and endocrine disruption is commonly reported in aquatic species exposed to complex contaminant mixtures. We previously reported that Atlantic killifish (Fundulus heteroclitus) from the chronically contaminated Newark Bay, NJ, exhibit multiple endocrine disrupting effects, including inhibition of vitellogenesis (yolk protein synthesis) in females and false negative vitellogenin biomarker responses...
The temporal and spatial variability of crescentic sandbars is analyzed with hourly
long-term (months) video observations collected at four barred sites and are qualitatively
compared to the temporal and spatial variability predicted by hypotheses underpinning
existing approaches and models for crescentic bar formation (edge-wave template model,
linear stability analysis, and...