The echinoderm axial organ is located centrally, at the meeting point of the
animals' "circulatory" systems. This, and its unusual histology, have prompted
the implication of a number of different functions for the organ, including
circulation, excretion and host defense. None of these have been definitively
proven. Claims that starfish...
The relationship of intracellular drug levels and resultant drug activity to intracellular pH (pHi) was studied in the experimental tumors. Glucose (5 g/kg) and/or sodium oxamate (0.1 mmol) were administered to Walker 256 ascites cells and Ehrlich ascites cells, in an attempt to alter pHi as measured by the distribution...
The toxicity of chlorobenzene (CB) was investigated in rainbow
trout following acute ip administration (1. 0 ml/kg, 1:1 in corn oil)
and chronic exposure (2. 1 ppm and 2. 9 ppm) via the water in a continuously
flowing system for 15 and 30 days.
In the acute study, overt toxicity...
Male Sprague Dawley rats received a single intraperitoneal dose
of BCNU in experiments designed to measure biochemical changes associated with the pulmonary toxicity described for this agent. Changes in
serum and lung lavage angiotensin converting enzyme (ACE) activity
were measured to detect changes in pulmonary endothelial cell integrity. Alpha-1-proteinase inhibitor...
The hepatotoxicity of CB was studied in the Sprague-Dawley rat and rainbow trout. In rats, an ip dosage of 9.8 mmol/kg CB (~̲ LD10) produced evidence of liver toxicity over a 72 hr time course. Sulfobromophthalein (BSP) retention maximized 3-16 hr post treatment and normalized after 72 hr whereas plasma...
Pentobarbital binding to hemoglobin, evidence of an interaction
between pentobarbital and 2,3-DPG in binding to hemoglobin, and the
effect of altered oxygen dissociation on the outcome of barbiturate
poisoning were studied.
Ultrafiltration and equilibrium dialysis techniques were used to
determine the binding of pentobarbital to solutions of purified
hemoglobin, diluted...
Previous investigation showed that 20 mg/kg BCNU
caused inhibition of sulfobromophthalein (BSP) excretion
and inhibited bile salt independent bile flow (BSIF) in
rats by 48 h after treatment (Hoyt, 1984).
The present investigation demonstrated that BCNU
inhibited the canalicular step in the excretion of BSP.
This was indicated by the...