Index Catalog // ScholarsArchive@OSU

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Creator:: Kesinger, Nicholas G.
Abstract:: Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'. The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
Resource Type:: Dissertation

Growth and characterization of wide–gap semiconducting oxide and chalcogenide thin films by pulsed laser deposition

Creator:: Newhouse, Paul F.
Abstract:: The preparation and characterization of thin film oxides and chalcogenides by pulsed laser deposition (PLD) is presented. An overview of fundamental PLD concepts are presented and are followed by a description implementation and development of the PLD systems at OSU. We present the results of thin film growth of high...
Resource Type:: Dissertation

Strategies for the Synthesis of Nitrogeous Compounds : Aminal Radical Reaction and Pyridinium Oxide Cycloadditions

Creator:: Lu, Yi
Abstract:: Pharmaceuticals, molecular catalysts, and secondary metabolites often contain nitrogen. The problems faced synthesizing compounds which contain nitrogen was because of the Lewis base reactivity of nitrogen lone pairs, and the acidic protons of some nitrogenous functional groups. We developed two methods for the synthesis of nitrogeous compounds. Additionally, we successfully...
Resource Type:: Dissertation

Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

Creator:: Wierzbicki, Igor H.
Abstract:: The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
Resource Type:: Dissertation
Full Text:: and help with all of the overwhelming paper work; Dr. McPhail for being part of my graduate

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

Creator:: Serrill, Jeffrey D.
Abstract:: Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
Resource Type:: Dissertation
Full Text:: academics. I would like to thank Dr. Kerry McPhail for acting as an active, supportive collaborator, and

Biosynthesis and modification of the antibiotic enduracidin

Creator:: Goebel, Neal C.
Abstract:: The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
Resource Type:: Dissertation
Full Text:: Mahmud. Phil Proteau and Kerry McPhail. It has been a privilege to have worked with you. The advice and

Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

Creator:: Hau, Andrew M.
Abstract:: Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...
Resource Type:: Dissertation
Full Text:: . Proteau and Kerry L. McPhail. TABLE OF CONTENTS Page CHAPTER ONE: GENERAL INTRODUCTION

Dynamic seascapes : a quantitative framework for scaling pelagic ecology and biogeochemistry

Creator:: Kavanaugh, Maria T.
Abstract:: Understanding and modeling microbial responses and feedbacks to climate change is hampered by a lack of a framework in the pelagic environment by which to link local mechanism to large scale patterns. Where terrestrial ecology draws from landscape theory and practice to address issues of scale, the pelagic seascape concept...
Resource Type:: Dissertation
Full Text:: , including Curt Davis, Burke Hales, Yvette Spitz, Evelyn Sherr, Lisa Madsen, and Kerry McPhail. You all

A Diels-Alder approach to biaryl synthesis

Creator:: Ashburn, Bradley O.
Abstract:: An expedient approach to the synthesis of a wide range of highly programmable biaryl templates has been accomplished. Utilizing the Diels-Alder [4+2] cycloaddition, a wide range of tri- and tetra-ortho-substituted biaryls have been synthesized in only three to four steps from commercially available materials. We have successfully synthesized entire classes...
Resource Type:: Dissertation
Full Text:: . Paul R. Blakemore, Prof. Kerry L. McPhail, and Prof. William W. Warren for their guidance. I want to

Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

Creator:: Ferreira, Andrew
Abstract:: The first part of this manuscript is about the total synthesis of the Arundo donax bis(indole) natural products. The A. donax alkaloids were prepared using the first example of an ynindole Diels–Alder reaction. Each were then separated, isolated, and determined to have stable enantiomeric conformations at room temperature (Chen, J.;...
Resource Type:: Dissertation

ScholarsArchive@OSU

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Growth and characterization of wide–gap semiconducting oxide and chalcogenide thin films by pulsed laser deposition

Strategies for the Synthesis of Nitrogeous Compounds : Aminal Radical Reaction and Pyridinium Oxide Cycloadditions

Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

Biosynthesis and modification of the antibiotic enduracidin

Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

Dynamic seascapes : a quantitative framework for scaling pelagic ecology and biogeochemistry

A Diels-Alder approach to biaryl synthesis

Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

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