Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
This Thesis aims to determine whether we can improve the accuracy, resolution, and speed of calculations for common power system problems using simple computational models that scale well to machine learning and high performance computing solutions. The second chapter of this Thesis implements more precise aging and degradation models for...
Cell membranes act as barriers against unwanted movement of ions and biomolecules and are complex surfaces littered with protein channels, ion channels, cholesterol, and a myriad of different proteins. While this surface is extremely well studied, there is still much we do not know. The work in this dissertation demonstrates...
Having a series of excellent properties, the oxide dispersion-strengthened (ODS) steels provide promising solutions for the challenges of structural materials in nuclear energy, especially the development of future advanced nuclear fission and even fusion reactors. The current manufacturing route for ODS alloys includes mechanical alloying (MA) of master alloys or...
This study examines the ways in which land-use regulations in general and Oregon’s land-use planning system in particular may affect property values. The study is focused on Oregon, but it is framed within the broader context of research in economics. Our analysis of Oregon land value data finds no evidence...
The effects of mold level (Botrytis cinerea), processing method (fresh, individually quick frozen (IQF), frozen sugared sliced (FSS), freeze dried (FD), canned, and preserves), and maturity (underripe, normal, and overripe) and strawberry volatiles were analyzed by gas liquid chromatography (GLC) using on-column entrainment of headspace volatiles in aqueous extracts. Computerized...
The purpose of this study was to explore the lived experiences of school-based agriculture education (SBAE) teachers who self-identified as blended pedagogues. This study specifically focused on SBAE teachers' beliefs and how those beliefs influence their blended teaching classroom practice. Teacher beliefs are personal, subjective, and temporally and contextually stable....
The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
Sulforaphane is an isothiocyanate derived from cruciferous vegetables and has been under investigation as a cancer chemopreventive agent for over two decades. The compound is well tolerated and has been shown to slow cancer progression in several different pre-clinical models of carcinogenesis, such as of the lung, breast and colon....
"This study examines the ways in which land-use regulations in general and Oregon's land-use planning system in particular may affect property values. The study is focused on Oregon, but it is framed within the broader context of research in economics. Our analysis of Oregon land value data finds no evidence...