Back pain is the leading cause of disability worldwide, entailing a significant socioeconomic impact. A primary source of back pain can be attributed to intervertebral disc (IVD) degeneration allowing nerve ingrowth, facet joint arthritis, disc bulging, and osteophyte formations that press on nearby nerve roots or the spinal cord. While...
The structural and stress changes in molybdenum/amorphous silicon (Mo/a-Si)
EUV reflecting multilayers during annealing at 316°C were studied. The amorphous
interlayers, with an Mo:Si stoichiometry of 1:2, grew during annealing. The residual
stresses in each component of the multilayer also changed significantly. Through high
resolution electron microscopy, selected area electron...
Sensory hair cells convert mechanical motion into chemical signals. Otoferlin, a six-C2 domain transmembrane protein linked to deafness in humans, is hypothesized to play a
role in exocytosis at hair cell ribbon synapses. To date however, otoferlin has been
studied almost exclusively in mouse models, and no rescue experiments have...
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encoding mouse otoferlin was a gift from Christine Petit (Institut Pasteur, 147
Paris, France). The p5E
The use of zebrafish in behavioral neuroscience is rapidly growing. Zebrafish can be assessed for alterations in multiple behavioral endpoints, creating opportunities to use this powerful model to identify chemicals that alter behavioral phenotypes. To evaluate the utility of zebrafish for neurotoxicity research, we designed custom instrumentation to evaluate numerous...
The marine cyanobacterium Lyngbya majuscula has proven to be extraordinarily rich in bioactive secondary metabolites. This dissertation describes the chemistry of L. majuscula collected from Grenada, Fiji and Papua New Guinea, and the biosyntheses of two L. majuscula metabolites, curacin A and barbamide.
The chemical studies with a Grenada collection...
The number of wildland–urban interface communities affected by wildfire is increasing, and both wildfire suppression and losses are costly. However, little is known about post-wildfire response by homeowners and communities after buildings are lost. Our goal was to characterise rebuilding and new development after wildfires across the conterminous United States....
Negative impacts of CO₂-induced ocean acidification on marine organisms have proven to be variable both among and within taxa. For fishes, inconsistency confounds our ability to draw conclusions that apply across taxonomic groups and highlights the limitations of a nascent field with a narrow scope of study species. Here, we...
Ambifunctional axially chiral 2,2',6,6'-tetrasubstituted biphenyls containing nucleophilic (or basic) functional groups juxtaposed with hydrogen-bond donors were synthesized and their properties studied. Applications for the prepared biaryls as potential organocatalysts for enantioselective carbon-carbon bond forming reactions were examined. Processes investigated included: aldol, Michael, nitroaldol (Henry), and Baylis-Hillman reactions.
The novel amidoamine...
This set of studies delve into the complex realm of healthy sexuality within sexual addiction treatment, where diverse perspectives often lead to confusion and suboptimal outcomes. The primary goal of most treatment models is guiding clients toward a healthier sexual experience.
Sex addiction, a complex phenomenon, involves compulsive sexual behaviors,...