This dissertation explores the real world problem of rural youth out-migration and finds that the central problem is one of persistent class difference in this rural Oregon town. The research that informs this dissertation was conducted in a rural community of approximately 2300 residents in Eastern Oregon, here called Talltown....
Monocrotaline (MCT) is a member of a class of naturally occurring
phytotoxins known as pyrrolizidine alkaloids (PAs). Exposure to PAs can result
in liver and cardiopulmonary lesions as well as lymphoid organ atrophy. In the
present study C57BI/6 (B6) mice received MCT (0-150 mg/kg/day, po) for 14
days. Overt toxicity...
The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
In experimentally exposed mice, the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) produces significant suppression of adaptive immune responses at low doses. However, the underlying biochemical and cellular mechanisms of TCDD-induced immunotoxicity have remained elusive since the identification of these effects nearly 30 years ago. Antigen-presenting cells (APC) constitute various populations of...
This dissertation is situated as the third work in a series on academic women. In 1964,
Jessie Bernard published Academic Women, which provided a comprehensive
assessment of the status of women in academia. Two decades later, in 1987, Angela
Simeone offered insight into attempts to achieve equity for women in...