Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the
increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways
that could be responsible for rapamycin’s longevity effect,...
Full Text:
in the Liver
Transcriptome
Wilson C. Fok1, Yidong Chen3,4,5, Alex Bokov2,3, Yiqiang Zhang2,6, Adam B
Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the
increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways
that could be responsible for rapamycin’s longevity effect,...
Rapamycin (Rapa) and dietary restriction (DR) have consistently
been shown to increase lifespan. To investigate whether Rapa
and DR affect similar pathways in mice, we compared the effects
of feeding mice ad libitum (AL), Rapa, DR, or a combination of
Rapa and DR (Rapa + DR) on the transcriptome and...
Full Text:
dietary restriction has a
larger effect on the transcriptome and metabolome of liver
Wilson C. Fok,1 Alex
Rapamycin (Rapa) and dietary restriction (DR) have consistently
been shown to increase lifespan. To investigate whether Rapa
and DR affect similar pathways in mice, we compared the effects
of feeding mice ad libitum (AL), Rapa, DR, or a combination of
Rapa and DR (Rapa + DR) on the transcriptome and...
Rapamycin (Rapa) and dietary restriction (DR) have consistently
been shown to increase lifespan. To investigate whether Rapa
and DR affect similar pathways in mice, we compared the effects
of feeding mice ad libitum (AL), Rapa, DR, or a combination of
Rapa and DR (Rapa + DR) on the transcriptome and...
Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways that could be responsible for rapamycin's longevity effect,...
We present multiple lines of evidence for years to decade-long changes in the location and
character of volcanic activity at West Mata seamount in the NE Lau basin over a 16 year period, and a hiatus
in summit eruptions from early 2011 to at least September 2012. Boninite lava and...
We present multiple lines of evidence for years to decade-long changes in the location and
character of volcanic activity at West Mata seamount in the NE Lau basin over a 16 year period, and a hiatus
in summit eruptions from early 2011 to at least September 2012. Boninite lava and...
Full Text:
, Kenneth H. Rubin4, John E. Lupton1,
Joseph A. Resing5, Robert P. Dziak2, Marvin D. Lilley6, William W