Circadian clocks are endogenous molecular mechanisms that coordinate daily rhythms in gene expression, cellular activities, and physiological functions with external day/night cycles. Breakdown of circadian rhythms such as sleep/wake cycles is associated with the onset of several neurological diseases; however, it is not clear whether disruption of rhythms is a...
Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics.
Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...
In this dissertation I study evolutionary patterns at genes encoding antimicrobial peptides (AMPs) in frogs. AMPs are short, amphipathic, cationic, secreted proteins that kill bacteria and other pathogens through a non-catalytic mechanism that involves
binding to and disrupting the microbial cell membrane. In many animal taxa, positive selection is much...
Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...
Respiratory Syncytial Virus (RSV) is a leading cause of bronchopneumonia in infants and elderly. Knowledge of viral and host protein interactions is important for better understanding of the viral pathogenesis and may lead to development of novel therapeutic drugs. Here, we show that RSV Matrix (M) protein interacts with cellular...
An analog signal processing technique allowing arbitrary step
response is presented. A transversal structure is used with
nonuniform contradirectional coupling to provide continuous tapping.
Sinusoidal and chirp responses are presented as examples implemented
using this nonuniformly coupled microstrip structure.
Tidal wetland channels provide rearing habitat for juvenile Chinook salmon as they emigrate from freshwater habitat and prepare to enter the ocean. Widespread diking and drainage of estuarine marshes for agricultural and urban development may have contributed to a decline in salmon abundance in the Pacific Northwest, prompting efforts to...
The promotion of out of school physical activity during physical education has received increasing attention as a tool for combating increasing sedentary time among youth. Qualitative work has shown that physical education teachers feel they lack the knowledge necessary to include physical activity promotion in their lessons and unprepared by...
The decline of many Pacific salmon stocks has stimulated interest in the early life history and habitat requirements of juvenile salmon. Although estuarine habitat associations of juvenile salmon have been investigated in many coastal areas of the eastern Pacific Ocean, until recently, little was known about juvenile salmonid ecology within...
Exposure to ultraviolet (UV) radiation is a primary cause of melanoma and non-melanoma skin cancer and thus represents a critical public health concern. Skin cancer risk behavior research lacks an instrument designed to assess health beliefs about UV exposure that may increase skin cancer risk by increasing risky UV exposure...