This thesis describes the chemical investigation of marine cyanobacteria collected in Madagascar and Panama with an emphasis on the isolation and structure elucidation of medicinally relevant secondary metabolites.
A collection of the marine cyanobacterium Lyngbya majuscula from the Radames Islands, Madagascar yielded two new cyclic depsipeptides, radamamides A and B,...
A low-energy, low-exposure-rate, guarded-field ionization
chamber system with a sensitive volume of approximately 1040 cm³ and an exposure-rate range from 60 mR/h to less than 0.5 mR/h
was designed, constructed and calibrated. The calibration was
effected by constructing and calibrating a 60 cm³ volume transfer
chamber of similar design against...
The asymmetric nature of bit errors in several practical applications provides grounds for efficient error control techniques. The Z-channel model and special classes of codes like asymmetric error detection codes and t-asymmetric error correcting/d-asymmetric error detecting codes can be successfully used in ARQ protocols for feedback error control enhancement. This...
Thiamin is an essential nutrient in the human diet. Severe thiamin deficiency leads to beriberi, a lethal disease which is common in developing countries. Thiamin biofortification of staple food crops is a possible strategy to alleviate thiamin deficiency-related diseases. In plants, thiamin plays a role in the response to abiotic...
The purpose of this thesis is to analyze an abrupt case of climate change in the past as a means to understand the mechanisms that force climate change. By looking to past analogs of climate change, we hopefully will gain an understanding of these events, which could be used to...
Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...
Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome’s integrity, whether as a consequence of inherited defects or induced via exposure to environmental agents (chemicals, biological agents and radiation). Thus, genome instability can be defined as an enhanced...
Article 1: Behavior of Epoxy Injected Diagonally Cracked Full-Scale CRC Deck-Girders.
Many cast-in place reinforced concrete deck-girder bridges (RCDG) remain in the national inventory and exhibit diagonal cracking. Epoxy injection has been in use for several decades as a method for sealing diagonal cracks, but the effects on girder behavior...