RNA sequencing (RNA-Seq) is the current method of choice for characterizing transcriptomes and
quantifying gene expression changes. This next generation sequencing-based method provides unprecedented
depth and resolution. The negative binomial (NB) probability distribution has been shown to be a
useful model for frequencies of mapped RNA-Seq reads and consequently provides...
Phytophthora root rot decreases availability and quality of rhododendrons produced in the USA. Symptoms of Phytophthora root rot include root necrosis, leaf chlorosis, stunting, and permanent wilt. The purpose of this thesis was to better understand the impact of root damage, soil moisture, nitrogen fertilizer application, and pathogen species on...
Pseudomonas syringae are plant pathogenic bacteria that cause disease by rapidly multiplying within the aboveground tissues of host plants. Growth of P. syringae within plant host tissues requires the disarmament of host immune defenses that limit microbial growth. To combat host defenses, P. syringae deploys a type III secretion system...
Acetylene is a slow-binding inhibitor of the Ni- and Fe-containing dimeric hydrogenase isolated
from Azotobacter vinelandii. Acetylene was released from hydrogenase during the recovery from inhibition.
This indicates that no transformation of acetylene to another compound occurred as a result of the interaction
with hydrogenase. However, the release of C2H2...
This study represents a novel approach for intraoperative ovarian cancer treatment based on the combinatorial effect of a targeted photodynamic therapy (PDT) associated with suppression of the DJ-1 protein, one of the key players in the ROS defense of cancer cells. To assess the potential of the developed therapy, dendrimer-based...
In this dissertation, I present experimental observations of multiply charged atomic ions (MCAI) generated from interactions of atomic/molecular clusters with moderately intense nanosecond laser pulses. This process is also known as Coulomb explosion (CE) and it has been extensively studied in intense laser fields using ultrashort pulses. Several prevailing theories...
Plasma biochemistry and hematology reference intervals are integral health assessment tools in all medical fields, including aquatic animal health. As sablefish (Anoplopoma fimbria) are becoming aquaculturally and economically more important, this manuscript provides essential reference intervals (RI) for their plasma biochemistry and hematology along with reference photomicrographs of blood cells...
We studied the problem of resource allocation in large scale distributed applications such as Online Social Networks (OSN) and Cloud Computing. In such settings, resource allocation schemes need to efficient as well as adaptive to the time-varying environments. The abstract resource allocation problem concerns with how to optimally use resources...
Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...