The variable length, six-electrode plasma source for atomic
emission spectroscopy described here is operated from three
compact, simple, and inexpensive direct current power supplies. The
vertical arcs formed between the three electrode pairs completely
entrain the sample and are typically operated at 40 V and 20 A.
Three concentric quartz...
In this dissertation, my research work on excited state dynamics of small organic molecules in solutions is presented. Using femtosecond stimulated Raman spectroscopy (FSRS) as the main experimental tool, the excited state hydrogen-bonding dynamics (ESHBD) of Coumarin 102, a common laser dye molecule, in ethanol solution is examined with <150...
Deoxyribonucleoside triphosphate pools in mammalian mitochondria are highly
asymmetric, and this asymmetry probably contributes toward the elevated
mutation rate for the mitochondrial genome as compared with the nuclear
genome. To understand this asymmetry, we must identify pathways for synthesis
and accumulation of dNTPs within mitochondria. We have identified
ribonucleotide reductase...
Includes general information about journal costs and costs of commercial versus society publications. Spreadsheet represents the journals in which faculty in the Chemistry Department most often publish and includes journal title, cost, impact factor, publisher, and information about whether the journal is published by a scholarly society or a for-profit...
Intrinsically disordered protein (IDP) duplexes composed of two IDP chains cross-linked by bivalent partner proteins form scaffolds for assembly of multiprotein complexes. The N-terminal domain of dynein intermediate chain (N-IC) is one such IDP that forms a bivalent scaffold with multiple dynein light chains including LC8, a hub protein that...
The CARS apparatus at OSU was modified to permit studies in the 0-500 cm⁻¹ spectral region. The new low frequency capabilities were then used to study molecular clusters formed in free expansion jets of carbon dioxide. A strong cluster band was observed at 73 cm⁻¹, with a weaker shoulder at...
The high resolution stimulated Raman spectrometer at OSU was
modified to improve its sensitivity and to extend its range of
applications to low Raman shifts and to the spectroscopy of solids and
liquids. As part of the characterization of the spectrometer, optical
Stark effects on rotational and vibrational transitions of...
Elevated hepatic expression of fatty acid elongase-5 (Elovl5) induces
FoxO1 phosphorylation, lowers FoxO1 nuclear content and suppresses expression of
genes involved in gluconeogenesis. In this report we define the molecular and metabolic
basis of Elovl5 control of FoxO1 phosphorylation. Adenoviral-mediated (Ad-Elovl5)
induction of hepatic Elovl5 in diet induced obese-glucose intolerant...
Hub proteins bind a large number of partners to facilitate structural changes and downstream protein interactions. LC8, a highly conserved protein homodimer, is a unique hub that regulates the activity of proteins in a wide range of cellular processes by binding to intrinsically disordered regions. With many of these systems,...