Purpose of the Study: We tested a life-span model of combat exposure on posttraumatic stress disorder (PTSD) symptoms in later life, examining the direct and indirect effects of prewar, warzone, and postwar factors.
Design and Methods: The sample included 947 male World War II and Korean War veterans from the...
This paper presents a new mechanical design of an anthropomorphic robot hand. The hand is designed such that it is adaptive, backdrivable, modularized to provide both dexterity and robustness. The hand has 18 joints, 14 degrees of freedom, and a new joint mechanism called an active DIP-PIP joint for the...
The need for sustainably powering unobtrusive internet-of-things applications has led to an interest in energy harvesting. Particularly, the proliferation of wireless communication and devices in the 2.4 GHz Industrial Scientificc Medical (ISM) band creates an opportunity to leverage commonly used devices for RF powering. This dissertation presents a low-quiescent-power...
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
Full Text:
colon cancer cells
HDAC8 and STAT3 repress BMF gene activity in colon cancer cells
Kang, Y., Nian, H
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
It has been demonstrated that walking is the most common form of physical activity for adults with intellectual disabilities, including Down syndrome (DS). The pedometer is common measurement tool to quantify steps walked, yet there is little evidence of the psychometric properties for individuals with intellectual disabilities, particularly DS. Thus,...
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
Background:
The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The current investigation sought to examine the relationships between Nrf2 status and HDAC expression in preclinical and translational studies.
Results:
Wild type...
Background:
The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The current investigation sought to examine the relationships between Nrf2 status and HDAC expression in preclinical and translational studies.
Results:
Wild type...
Full Text:
growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon
Nrf2 status
Background:
The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The current investigation sought to examine the relationships between Nrf2 status and HDAC expression in preclinical and translational studies.
Results:
Wild type...
Full Text:
: Table S1
No. Gene Symbol Gene Name
Fold change compared to normal colon in
WT vehicle controls