2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Lymphomas and leukemias are the most common cancer in children and young adults and in utero exposure to carcinogens may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/Kg b.w., gavage) on gestation day 17. Significant mortalities in...
Over the last decade the world has seen three major tsunamis strike the coasts of
Indonesia, Samoa, and Chile. These tsunamis have caused significant losses of life and
property on the coastal cities of these and nearby countries. The NEES (Network for
Earthquake Engineering Simulation) Housesmash project was created to...
Coastal flooding and erosion are major concerns for low lying coastal communities -- particularly in light of accelerated sea level rise and climate change. To improve quantitative understanding of the physical drivers of both flooding and coastal landscape change, this dissertation explores coastal morphodynamics bridging the land-sea interface on modally...
A three-part algorithm is described and tested to provide robust bathymetry maps based solely on long time series observations of surface wave motions. The first phase consists of frequency-dependent characterization of the wave field in which dominant frequencies are estimated by Fourier transform while corresponding wave numbers are derived from...
In this dissertation the interactions between hydrodynamics, sediment suspension and transport, and morphological evolution in the surf zone was investigated with a large-scale laboratory experiment data, CROss-Shore Sediment Transport Experiment (CROSSTEX). The data set included comprehensive measurements of water surface elevation, fluid velocity, sediment concentration, and morphology for irregular waves...
BACKGROUND: Targeted capture of genomic regions reduces sequencing cost while generating higher coverage by
allowing biomedical researchers to focus on specific loci of interest, such as exons. Targeted capture also has the
potential to facilitate the generation of genomic data from DNA collected via saliva or buccal cells. DNA samples...
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plots illustrates the relative abundance (y-axis) of the most abundant oral microbiota at
the A) genus