Multicellular eukaryotes produce small RNA molecules (approximately 21–24 nucleotides) of two general types, microRNA (miRNA) and short interfering RNA (siRNA). They collectively function as sequence-specific guides to silence or regulate genes, transposons, and viruses and to modify chromatin and genome structure. Formation or activity of small RNAs requires factors belonging...
Water quality agencies and scientists are increasingly adopting standardized sampling methodologies because of the challenges associated with interpreting data derived from dissimilar protocols. Here, we compare 13 protocols for monitoring streams from different regions and countries around the globe. Despite the spatially diverse range of countries assessed, many aspects of...
Nitrogen is one of the major nutrients limiting microbial productivity in the ocean, and as a result, most marine microorganisms
have evolved systems for responding to nitrogen stress. The highly abundant alphaproteobacterium “Candidatus
Pelagibacter ubique,” a cultured member of the order Pelagibacterales (SAR11), lacks the canonical GlnB, GlnD, GlnK, and...
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PII-Independent Response to Nitrogen
Limitation in a Free-Living Alphaproteobacterium
Daniel P. Smith
Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin-1 receptor–associated kinase 4 (IRAK4) is a critical modulator of inflammation, inhibition of its activity with selective drug molecules (IRAK4 inhibitors) represents a promising therapeutic strategy for inflammatory disorders. To exploit the full potential of this...
Estimating the abundance of long-lived, migratory animals is challenging but essential
for managing populations. We provide the first abundance estimates of endangered humpback
whales Megaptera novaeangliae from their breeding grounds in Oceania, South Pacific.
Using fluke photo-identification (1999−2004, n = 660 individuals) and microsatellite genotypes
(1999−2005, n = 840 individuals),...
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. Scott Baker,
Lyndon Brooks, Daniel Burns, Phillip Clapham, Nan Hauser, Bénédicte Madon,
David Mattila
Endogenous small RNAs (endo-siRNAs) interact with Argonaute (AGO) proteins to mediate
sequence-specific regulation of diverse biological processes. Here, we combine deep-sequencing and
genetic approaches to explore the biogenesis and function of endo-siRNAs in C. elegans. We describe
conditional alleles of the dicer-related helicase, drh-3, that abrogate both RNA interference and...
This edition contains research updates and a comprehensive list of publications summarizing research conducted by faculty of the Oregon Wine Research Institute at Oregon State University. Dr. Elizabeth Tomasino, OSU Associate Professor, opens the newsletter with an article on the influence of two compounds on Pinot noir aroma. Drs. Laurent...
We present the WD2014 chronology for the upper
part (0–2850 m; 31.2 ka BP) of the West Antarctic Ice Sheet
(WAIS) Divide (WD) ice core. The chronology is based on
counting of annual layers observed in the chemical, dust
and electrical conductivity records. These layers are caused
by seasonal changes...
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, Lawrence Layman1, Olivia J. Maselli1, Kenneth McGwire1, Raimund Muscheler8,
Kunihiko Nishiizumi6, Daniel R
An Expert Panel convened by the National Lipid Association previously developed a consensus set of recommendations for the patient-centered management of dyslipidemia in clinical medicine (part 1). These were guided by the principle that reducing elevated levels of atherogenic cholesterol (non–high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) reduces the risk...
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, MPH, Chair; Jonathon S. Coblyn, MD; Jeffrey Curtis, MD, MS, MPH; Jorge Plutzky, MD, FNLA;
Daniel
Human alterations to nutrient cycles[superscript 1,2] and herbivore communities³⁻⁷
are affecting global biodiversity dramatically². Ecological theory predicts
these changes should be strongly counteractive: nutrient addition
drives plant species loss through intensified competition for
light, whereas herbivores prevent competitive exclusion by increasing
ground-level light, particularly in productive systems[superscript 8,9]. Here we...