Rockfishes, Sebastes spp.. were the most numerous and speciose fishes seen during 16 submersible dives from 64 to 305 m depth in the vicinity of Heceta Bank off the coast of Oregon. Dense schools of juvenile rockfishes and large yellowtail rockfish, S. flavidus, were observed only over rocky, high relief...
Heterotrophic respiration (HR), the aerobic and anaerobic processes mineralizing organic matter, is a key carbon flux but one impossible to measure at scales significantly larger than small experimental plots. This impedes our ability to understand carbon and nutrient cycles, benchmark models, or reliably upscale point measurements. Given that a new...
The issue of permanent nondipole contributions to the time-averaged field lies at the very heart of
paleomagnetism and the study of the ancient geomagnetic field. In this paper we focus on paleomagnetic
directional results from igneous rocks of the southwestern U.S.A. in the age range 0–5 Ma and investigate
both...
The summit crater of Vailulu’u Seamount, the youngest volcano in the Samoan chain, hosts an active
hydrothermal system with profound impact on the ocean water column inside and around its crater (2 km
wide and 407 m deep at a 593 m summit depth). The turbidity of the ocean water...
Feedback loops involving soil microorganisms can
regulate plant populations. Here, we hypothesize that microorganisms
are most likely to play a role in plant–soil feedback
loops when they possess an affinity for a particular plant and
the capacity to consistently affect the growth of that plant for
good or ill. We...
Full Text:
H. M. Ramirez & Christy L. Sprague &
Anthony C. Yannarell
Received: 16 July 2013 /Accepted: 10
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Full Text:
, Atsushi Nakagawa, Haruki
Nakamura, AnthonyNicholls, Marc Nicklaus, Robert T. Nolte, Anil K.
Padyana
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Full Text:
Nakamura,28 AnthonyNicholls,15
Marc Nicklaus,29 Robert T. Nolte,30 Anil K. Padyana,31 Catherine E
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Enterococci are among the leading pathogens isolated in hospital-acquired infections. Current antimicrobial options for vancomycin-
resistant enterococci (VRE) are limited. Prior data suggest that daptomycin at>6 mg/kg of body weight/day may be used
to treat enterococcal infections. We retrospectively evaluated the effectiveness and safety of high-dose daptomycin (HD-daptomycin)
therapy (>6...
Polymorphonuclear leukocytes (PMN) from patients with chronic granulomatous disease (CGD) fail to produce microbicidal concentrations of reactive oxygen species (ROS) due to mutations in NOX2. Patients with CGD suffer from severe, life-threatening infections and inflammatory complications. Granulibacter bethesdensis is an emerging Gram-negative pathogen in CGD that resists killing by PMN...