Cell membranes act as barriers against unwanted movement of ions and biomolecules and are complex surfaces littered with protein channels, ion channels, cholesterol, and a myriad of different proteins. While this surface is extremely well studied, there is still much we do not know. The work in this dissertation demonstrates...
A two-dimensional numerical mesoscale model, which ic1udes
radiative and turbulent transfers, has been constructed to study the
formation, development and dissipation of coastal stratus cloud
under an inversion. In the model, the delta-Eddington and emissivity
approximations are used for the solar and thermal radiative
transfers, respectively. K-theory parameterization is adopted...
At a time when environmental conditions are rapidly changing, understanding how thermal extremes impact wildlife is imperative to fully understanding the consequences of climate change in natural ecosystems. While many organisms are currently impacted by rapidly warming and more erratic environmental conditions, identifying and investigating model species whose life histories...
American meteorology was synonymous with subjective weather forecasting in the early twentieth century. Controlled by the Weather Bureau and with no academic programs of its own, the few hundred extant meteorologists had no standing in the scientific community. Until the American Meteorological Society was founded in 1919, meteorologists had no...
Hybrid programs can often be a desirable option for students entering a graduate program in counseling. However, the rigor of such programs, including academic challenges and maintaining personal wellness, could be a barrier to students from marginalized social locations. Additional support through a hybrid orientation might help these students address...
The symbiosis between cnidarians (e.g., corals or sea anemones) and intracellular dinoflagellate algae of the genus Symbiodinium is of immense ecological importance. In particular, this symbiosis promotes the growth and survival of reef corals in nutrient-poor tropical waters; indeed, coral reefs could not exist without this symbiosis. However, our fundamental...
BACKGROUND: Cell lineage-specific DNA methylation patterns distinguish normal human leukocyte subsets and can
be used to detect and quantify these subsets in peripheral blood. We have developed an approach that uses DNA
methylation to simultaneously quantify multiple leukocyte subsets, enabling investigation of immune modulations
in virtually any blood sample including...
Full Text:
., Wiencke, J. K., Houseman, E. A., Nelson, H. H., & Kelsey, K.
T. (2014). Quantitative reconstruction of
A time-domain model was developed to predict the fluid/structure
interaction of a three-dimensional deformable body in a fluid domain subject to
long-crested finite amplitude waves. These nonlinear waves induce transient
motion in the body. In turn, the interaction of the body with the waves modifies
the wave field, causing additional...
Clostridium perfringens type A is a common source of food poisoning (FP) and non-food-borne (NFB) gastrointestinal diseases in humans. In the intestinal tract, the vegetative cells sporulate and produce a major pathogenic factor, C. perfringens enterotoxin (CPE). Most type A FP isolates carry a chromosomal cpe gene, whereas NFB type...
In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response (DDR). Oxidative stress and hyper-replication of genomic DNA have been proposed as major causes of DNA damage in OIS cells. Here we report that down-regulation of deoxyribonucleoside pools is another endogenous source of DNA damage in...