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- Creator:
- Fudge, T. J., Steig, Eric J., Markle, Bradley R., Schoenemann, Spruce W., Ding, Qinghua, Taylor, Kendrick C., McConnell, Joseph R., Brook, Edward J., Sowers, Todd, White, James W. C., Alley, Richard B., Cheng, Hai, Clow, Gary D., Cole-Dai, Jihong, Conway, Howard, Cuffey, Kurt M., Edwards, Jon S., Edwards, R. Lawrence, Edwards, Ross, Fegyveresi, John M., Ferris, David, Fitzpatrick, Joan J., Johnson, Jay, Hargreaves, Geoffrey, Lee, James E., Maselli, Olivia J., Mason, William, McGwire, Kenneth C., Mitchell, Logan E., Mortensen, Nicolai, Neff, Peter, Orsi, Anais J., Popp, Trevor J., and Schauer, Andrew J.
- Abstract:
- The cause of warming in the Southern Hemisphere during the most recent deglaciation remains a matter of debate[superscript 1,2]. Hypotheses for a Northern Hemisphere trigger, through oceanic redistributions of heat, are based in part on the abrupt onset of warming seen in East Antarctic ice cores and dated to 18,000...
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- (‰ ) WDC δ18O EDML δ18O EDC δ18O WDC ssNa ss N a (n g g– 1 ) δ1 8 O (‰ ) a b WDC WDC δ1818
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- Nahta, Rita, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Andrade-Vieira, Rafaela, Bay, Sarah N., Brown, Dustin G., Calaf, Gloria M., Castellino, Robert C., Cohen-Solal, Karine A., Colacci, Annamaria, Cruickshanks, Nichola, Dent, Paul, Di Fiore, Riccardo, Forte, Stefano, Goldberg, Gary S., Hamid, Roslida A., Krishnan, Harini, Laird, Dale W., Lasfar, Ahmed, Marignani, Paola A., Memeo, Lorenzo, Mondello, Chiara, Naus, Christian C., Ponce-Cusi, Richard, Raju, Jayadev, Roy, Debasish, Roy, Rabindra, Ryan, Elizabeth P., Salem, Hosni K., Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Vento, Renza, Vondráček, Jan, Wade, Mark, Woodrick, Jordan, and Bisson, William H.
- Abstract:
- As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth...
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- , Gloria M.Calaf6,7, Robert C.Castellino8, Karine A.Cohen-Solal9, Annamaria Colacci10, Nichola
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- Creator:
- Deans, Andrew R., Lewis, Suzanna E., Huala, Eva, Anzaldo, Salvatore S., Ashburner, Michael, Balhoff, James P., Blackburn, David C., Blake, Judith A., Burleigh, J. Gordon, Chanet, Bruno, Cooper, Lauren D., Courtot, Mélanie, Csösz, Sándor, Cul, Hong, Dahdul, Wasila, Das, Sandip, Dececchi, T. Alexander, Dettal, Agnes, Diogo, Rui, Druzinsky, Robert E., Dumontier, Michel, Franz, Nico M., Friedrich, Frank, Gkoutos, George V., Haendel, Melissa, Harmon, Luke J., Hayamizu, Terry F., He, Yongqun, Hines, Heather M., Ibrahim, Nizar, Jackson, Laura M., Jaiswal, Pankaj, James-Zorn, Christina, Köhler, Sebastian, Lecointre, Guillaume, Lapp, Hilmar, Lawrence, Carolyn J., Le Novère, Nicolas, Lundberg, John G., Macklin, James, Mast, Austin R., Midford, Peter E., Mikó, István, Mungall, Christopher J., Oellrich, Anika, Osumi-Sutherland, David, Parkinson, Helen, Ramírez, Martín J., Richter, Stefan, Robinson, Peter N., Ruttenberg, Alan, Schulz, Katja S., Segerdell, Erik, Seltmann, Katja C., Sharkey, Michael J., Smith, Aaron D., Smith, Barry, Specht, Chelsea D., Squires, R. Burke, Thacker, Robert W., Thessen, Anne, Fernandez-Triana, Jose, Vihinen, Mauno, Vize, Peter D., Vogt, Lars, Wall, Christine E., Walls, Ramona L., Westerfeld, Monte, Wharton, Robert A., Wirkner, Christian S., Woolley, James B., Yoder, Matthew J., Zorn, Aaron M., and Mabee, Paula
- Abstract:
- Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across...
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- , Ramona L. Walls56, Monte Westerfeld57, Robert A. Wharton58, Christian S. Wirkner38, James B. Woolley58
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- Creator:
- Armisen, David, Rajakumar, Rajendhran, Friedrich, Markus, Benoit, Joshua B., Robertson, Hugh M., Panfilio, Kristen A., Ahn, Seung-Joon, Poelchau, Monica F., Chao, Hsu, Dinh, Huyen, Doddapaneni, Harsha Vardhan, Dugan, Shannon, Gibbs, Richard A., Hughes, Daniel S. T., Han, Yi, Lee, Sandra L., Murali, Shwetha C., Muzny, Donna M., Qu, Jiaxin, Worley, Kim C., Munoz-Torres, Monica, Abouheif, Ehab, Bonneton, Francois, Chen, Travis, Chiang, Li-Mei, Childers, Christopher P., Cridge, Andrew G., Crumiere, Antonin J. J., Decaras, Amelie, Didion, Elise M., Duncan, Elizabeth J., Elpidina, Elena N., Fave, Marie-Julie, Finet, Cedric, Jacobs, Chris G. C., Jarvela, Alys M. Cheatle, Jennings, Emily C., Jones, Jeffery W., Lesoway, Maryna P., Lovegrove, Mackenzie R., Martynov, Alexander, Oppert, Brenda, Lillico-Ouachour, Angelica, Rajakumar, Arjuna, Refki, Peter Nagui, Rosendale, Andrew J., Santos, Maria Emilia, Toubiana, William, van der Zee, Maurijn, Jentzsch, Iris M. Vargas, Lowman, Aidamalia Vargas, Viala, Severine, Richards, Stephen, and Khila, Abderrahman
- Abstract:
- Background: Having conquered water surfaces worldwide, the semi-aquatic bugs occupy ponds, streams, lakes, mangroves, and even open oceans. The diversity of this group has inspired a range of scientific studies from ecology and evolution to developmental genetics and hydrodynamics of fluid locomotion. However, the lack of a representative water strider...
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- *, Rajendhran Rajakumar2, Markus Friedrich3, Joshua B. Benoit4, Hugh M. Robertson5, Kristen A. Panfilio6,7
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- Creator:
- Niu, Shuli, Luo, Yiqi, Fei, Shenfeng, Yuan, Wenping, Schimel, David, Law, Beverly E., Ammann, Christof, Arain, M. Altaf, Arneth, Almut, Aubinet, Marc, Barr, Alan, Beringer, Jason, Bernhofer, Christian, Black, T. Andrew, Buchmann, Nina, Cescatti, Alessandro, Chen, Jiquan, Davis, Kenneth J., Dellwik, Ebba, Desai, Ankur R., Etzold, Sophia, Francois, Louis, Gianelle, Damiano, Gielen, Bert, Goldstein, Allen, Groenendijk, Margriet, Gu, Lianhong, Hanan, Niall, Helfter, Carole, Hirano, Takashi, Hollinger, David Y., Jones, Mike B., Kiely, Gerard, Kolb, Thomas E., Kutsch, Werner L., Lafleur, Peter, Lawrence, David M., Li, Linghao, Lindroth, Anders, Litvak, Marcy, Loustau, Denis, Lund, Magnus, Marek, Michal, Martin, Timothy A., Matteucci, Giorgio, Migliavacca, Mirco, Montagnani, Leonardo, Moors, Eddy, Munger, J. William, Noormets, Asko, Oechel, Walter, Olejnik, Janusz, Paw U, Kyaw Tha, Pilegaard, Kim, Rambal, Serge, Raschi, Antonio, Scott, Russell L., Seufert, Gunther, Spano, Donatella, Stoy, Paul, Sutton, Mark A., Varlagin, Andrej, Vesala, Timo, Weng, Ensheng, Wohlfahrt, Georg, Yang, Bai, Zhang, Zhongda, and Zhou, Xuhui
- Abstract:
- It is well established that individual organisms can acclimate and adapt to temperature to optimize their functioning. However, thermal optimization of ecosystems, as an assemblage of organisms, has not been examined at broad spatial and temporal scales. Here, we compiled data from 169 globally distributed sites of eddy covariance and...
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- Hanan27, Carole Helfter28, Takashi Hirano29, David Y. Hollinger30, Mike B. Jones31, Gerard Kiely32
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- Creator:
- Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, and Young, Jasmine
- Abstract:
- Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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- , Atsushi Nakagawa, Haruki Nakamura, Anthony Nicholls, Marc Nicklaus, Robert T. Nolte, Anil K. Padyana
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- Creator:
- Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, and Young, Jasmine
- Abstract:
- Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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- Nakamura,28 Anthony Nicholls,15 Marc Nicklaus,29 Robert T. Nolte,30 Anil K. Padyana,31 Catherine E
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- Creator:
- Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, and Young, Jasmine
- Abstract:
- Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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- Article
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- Creator:
- Alford, Matthew H., Peacock, Thomas, MacKinnon, Jennifer A., Nash, Jonathan D., Buijsman, Maarten C., Centurioni, Luca R., Chao, Shenn-Yu, Chang, Ming-Huei, Farmer, David M., Fringer, Oliver B., Fu, Ke-Hsien, Gallacher, Patrick C., Graber, Hans C., Helfrich, Karl R., Jachec, Steven M., Jackson, Christopher R., Klymak, Jody M., Ko, Dong S., Jan, Sen, Johnston, T. M. Shaun, Legg, Sonya, Lee, I-Huan, Lien, Ren-Chieh, Mercier, Matthieu J., Moum, James N., Musgrave, Ruth, Park, Jae-Hun, Pickering, Andrew I., Pinkel, Robert, Rainville, Luc, Ramp, Steven R., Rudnick, Daniel L., Sarkar, Sutanu, Scotti, Alberto, Simmons, Harper L., St. Laurent, Louis C., Venayagamoorthy, Subhas K., Wang, Yu-Huai, Wang, Joe, Yang, Yiing J., Paluszkiewicz, Theresa, and Tang, Tswen-Yung (David)
- Abstract:
- Internal gravity waves, the subsurface analogue of the familiar surface gravity waves that break on beaches, are ubiquitous in the ocean. Because of their strong vertical and horizontal currents, and the turbulent mixing caused by their breaking, they affect a panoply of ocean processes, such as the supply of nutrients...
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- , Maarten C. Buijsman5, Luca R. Centuroni1, Shenn-Yu Chao6, Ming-Huei Chang7, David M. Farmer8{, Oliver B
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- Creator:
- Abazov, V. M., Abbott, B., Acharya, B. S., Adams, M., Adams, T., Agnew, J. P., Alexeev, G. D., Alkhazov, G., Alton, A., Askew, A., Atkins, S., Augsten, K., Aushev, V., Aushev, Y., Avila, C., Badaud, F., Bagby, L., Baldin, B., Bandurin, D. V., Banerjee, S., Barberis, E., Baringer, P., Bartlett, J. F., Bassler, U., Bazterra, V., Bean, A., Begalli, M., Bellantoni, L., Beri, S. B., Bernardi, G., Bernhard, R., Bertram, I., Besançon, M., Beuselinck, R., Bhat, P. C., Bhatia, S., Bhatnagar, V., Blazey, G., Blessing, S., Bloom, K., Boehnlein, A., Boline, D., Boos, E. E., Borissov, G., Borysova, M., Brandt, A., Brandt, O., Brochmann, M., Brock, R., Bross, A., Brown, D., Bu, X. B., Buehler, M., Buescher, V., Bunichev, V., Burdin, S., Buszello, C. P., Camacho-Pérez, E., Casey, B. C. K., Castilla-Valdez, H., Caughron, S., Chakrabarti, S., Chan, K. M., Chandra, A., Chapon, E., Chen, G., Cho, S. W., Choi, S., Choudhary, B., Cihangir, S., Claes, D., Clutter, J., Cooke, M., Cooper, W. E., Corcoran, M., Couderc, F., Cousinou, M.-C., Cuth, J., Cutts, D., Das, A., Davies, G., de Jong, S. J., De La Cruz-Burelo, E., Déliot, F., Demina, R., Denisov, D., Denisov, S. P., Desai, S., Deterre, C., DeVaughan, K., Diehl, H. T., Diesburg, M., Ding, P. F., Dominguez, A., Dubey, A., Dudko, L. V., Duperrin, A., Dutt, S., Eads, M., Edmunds, D., Ellison, J., Elvira, V. D., Enari, Y., Evans, H., Evdokimov, A., Evdokimov, V. N., Fauré, A., Feng, L., Ferbel, T., Fiedler, F., Filthaut, F., Fisher, W., Fisk, H. E., Fortner, M., Fox, H., Franc, J., Fuess, S., Garbincius, P. H., Garcia-Bellido, A., García-González, J. A., Gavrilov, V., Geng, W., Gerber, C. E., Gershtein, Y., Ginther, G., Gogota, O., Golovanov, G., Grannis, P. D., Greder, S., Greenlee, H., Grenier, G., Gris, Ph., Grivaz, J.-F., Grohsjean, A., Grünendahl, S., Grünewald, M. W., Guillemin, T., Gutierrez, G., Gutierrez, P., Haley, J., Han, L., Harder, K., Harel, A., Hauptman, J. M., Hays, J., Head, T., Hebbeker, T., Hedin, D., Hegab, H., Heinson, A. P., Heintz, U., Hensel, C., Heredia-De La Cruz, I., Hernández-Villanueva, M., Herner, K., Hesketh, G., Hildreth, M. D., Hirosky, R., Hoang, T., Hobbs, J. D., Hoeneisen, B., Hogan, J., Hohlfeld, M., Holzbauer, J. L., Howley, I., Hubacek, Z., Hynek, V., Iashvili, I., Ilchenko, Y., Illingworth, R., Ito, A. S., Jabeen, S., Jaffré, M., Jayasinghe, A., Jeong, M. S., Jesik, R., Jiang, P., Johns, K., Johnson, E., Johnson, M., Jonckheere, A., Jonsson, P., Joshi, J., Jung, A. W., Juste, A., Kajfasz, E., Karmanov, D., Katsanos, I., Kaur, M., Kehoe, R., Kermiche, S., Khalatyan, N., Khanov, A., Kharchilava, A., Kharzheev, Y. N., Kiselevich, I., Kohli, J. M., Kozelov, A. V., Kraus, J., Kumar, A., Kupco, A., Kurča, T., Kuzmin, V. A., Lammers, S., Lebrun, P., Lee, H. S., Lee, S. W., Lee, W. M., Lei, X., Lellouch, J., Li, D., Li, H., Li, L., Li, Q. Z., Lim, J. K., Lincoln, D., Linnemann, J., Lipaev, V. V., Lipton, R., Liu, H., Liu, Y., Lobodenko, A., Lokajicek, M., Lopes de Sa, R., Luna-Garcia, R., Lyon, A. L., Maciel, A. K. A., Madar, R., Magaña-Villalba, R., Malik, S., Malyshev, V. L., Mansour, J., Martínez-Ortega, J., McCarthy, R., McGivern, C. L., Meijer, M. M., Melnitchouk, A., Menezes, D., Mercadante, P. G., Merkin, M., Meyer, A., Meyer, J., Miconi, F., Mondal, N. K., Mulhearn, M., Nagy, E., Narain, M., Nayyar, R., Neal, H. A., Negret, J. P., Neustroev, P., Nguyen, H. T., Nunnemann, T., Orduna, J., Osman, N., Pal, A., Parashar, N., Parihar, V., Park, S. K., Partridge, R., Parua, N., Patwa, A., Penning, B., Perfilov, M., Peters, Y., Petridis, K., Petrillo, G., Pétroff, P., Pleier, M.-A., Podstavkov, V. M., Popov, A. V., Prewitt, M., Price, D., Prokopenko, N., Qian, J., Quadt, A., Quinn, B., Ratoff, P. N., Razumov, I., Ripp-Baudot, I., Rizatdinova, F., Rominsky, M., Ross, A., Royon, C., Rubinov, P., Ruchti, R., Sajot, G., Sánchez-Hernández, A., Sanders, M. P., Santos, A. S., Savage, G., Savitskyi, M., Sawyer, L., Scanlon, T., Schamberger, R. D., Scheglov, Y., Schellman, H., Schott, M., Schwanenberger, C., Schwienhorst, R., Sekaric, J., Severini, H., Shabalina, E., Shary, V., Shaw, S., Shchukin, A. A., Simak, V., Skubic, P., Slattery, P., Snow, G. R., Snow, J., Snyder, S., Söldner-Rembold, S., Sonnenschein, L., Soustruznik, K., Stark, J., Stefaniuk, N., Stoyanova, D. A., Strauss, M., Suter, L., Svoisky, P., Titov, M., Tokmenin, V. V., Tsai, Y.-T., Tsybychev, D., Tuchming, B., Tully, C., Uvarov, L., Uvarov, S., Uzunyan, S., Van Kooten, R., van Leeuwen, W. M., Varelas, N., Varnes, E. W., Vasilyev, I. A., Verkheev, A. Y., Vertogradov, L. S., Verzocchi, M., Vesterinen, M., Vilanova, D., Vokac, P., Wahl, H. D., Wang, M. H. L. S., Warchol, J., Watts, G., Wayne, M., Weichert, J., Welty-Rieger, L., Williams, M. R. J., Wilson, G. W., Wobisch, M., Wood, D. R., Wyatt, T. R., Xie, Y., Yamada, R., Yang, S., Yasuda, T., Yatsunenko, Y. A., Ye, W., Ye, Z., Yin, H., Yip, K., Youn, S. W., Yu, J. M., Zennamo, J., Zhao, T. G., Zhou, B., Zhu, J., Zielinski, M., Zieminska, D., Zivkovic, L., and D0 Collaboration
- Abstract:
- See article for Abstract.
- Resource Type:
- Article
- Full Text:
- B0s → J=ψ f 0ð980Þ V.M. Abazov,31 B. Abbott,67 B. S. Acharya,25 M. Adams,46 T. Adams,44 J. P. Agnew,41